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Volume 13
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Article

Retinal Structure Abnormalities in Parkinson’s Disease and Atypical Parkinsonism

by
Xinxin Ma
1,
Shuhua Li
1,
Bodi Zheng
2,
Lei Hu
2,
Huijing Liu
1,
Zheng Wang
2,
Zhaoxia Wang
3,
Haibo Chen
1 and
Wen Su
1,*
1
Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
2
Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
3
Department of Neurology, Peking University First Hospital, Beijing 100034, China
*
Author to whom correspondence should be addressed.
Biomolecules 2023, 13(2), 218; https://doi.org/10.3390/biom13020218
Submission received: 17 November 2022 / Revised: 17 January 2023 / Accepted: 20 January 2023 / Published: 23 January 2023
(This article belongs to the Special Issue Biomarkers and Risk Factors for Neurodegenerative Disease)
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Abstract

We investigated retinal structure changes in patients with Parkinson’s disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and controls, and explored the value of this method in differential diagnosis. Spectral domain optical coherence tomography (SD-OCT) was used to measure peripapillary retinal nerve fiber layer (pRNFL) thickness, and macular thickness and volume. PSP patients showed higher temporal pRNFL thickness than PD and MSA patients. Peripapillary RNFL thickness could be used for discriminating PSP from MSA and PD. PD and MSA patients showed retinal thinning in the foveal center circle and nasal inner sectors compared to controls. Macular thickness and volume could be used for discriminating MSA from PD. There were negative correlations between disease duration and OCT parameters in PD, MSA, and PSP, independent of age, sex ratio, and the side of the eye. PD and atypical parkinsonism correlate with specific patterns of retina alterations. OCT could be a biomarker for differential diagnosis and progression evaluation of parkinsonian syndrome.
Keywords: Parkinson’s disease; atypical parkinsonism; optical coherence tomography; multiple system atrophy; progressive supranuclear palsy Parkinson’s disease; atypical parkinsonism; optical coherence tomography; multiple system atrophy; progressive supranuclear palsy

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MDPI and ACS Style

Ma, X.; Li, S.; Zheng, B.; Hu, L.; Liu, H.; Wang, Z.; Wang, Z.; Chen, H.; Su, W. Retinal Structure Abnormalities in Parkinson’s Disease and Atypical Parkinsonism. Biomolecules 2023, 13, 218. https://doi.org/10.3390/biom13020218

AMA Style

Ma X, Li S, Zheng B, Hu L, Liu H, Wang Z, Wang Z, Chen H, Su W. Retinal Structure Abnormalities in Parkinson’s Disease and Atypical Parkinsonism. Biomolecules. 2023; 13(2):218. https://doi.org/10.3390/biom13020218

Chicago/Turabian Style

Ma, Xinxin, Shuhua Li, Bodi Zheng, Lei Hu, Huijing Liu, Zheng Wang, Zhaoxia Wang, Haibo Chen, and Wen Su. 2023. "Retinal Structure Abnormalities in Parkinson’s Disease and Atypical Parkinsonism" Biomolecules 13, no. 2: 218. https://doi.org/10.3390/biom13020218

APA Style

Ma, X., Li, S., Zheng, B., Hu, L., Liu, H., Wang, Z., Wang, Z., Chen, H., & Su, W. (2023). Retinal Structure Abnormalities in Parkinson’s Disease and Atypical Parkinsonism. Biomolecules, 13(2), 218. https://doi.org/10.3390/biom13020218

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