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Novel Nutraceutical Compounds in Alzheimer Prevention

1
International Center for Biomedicine ICC, Vitacura 3568, Santiago 7630000, Chile
2
Laboratory of Neuroscience and Functional Medicine, Faculty of Sciences, University of Chile, Santiago 7630000, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Stefania Sinicropi
Biomolecules 2022, 12(2), 249; https://doi.org/10.3390/biom12020249
Received: 14 December 2021 / Revised: 17 January 2022 / Accepted: 21 January 2022 / Published: 3 February 2022
(This article belongs to the Topic Compounds with Medicinal Value)
Alzheimer’s disease (AD) incidence is increasing worldwide at an alarming rate. Considering this increase, prevention efforts, stemming from scientific research, health education, and public policies, are critical. Clinical studies evidenced that healthy lifestyles along with natural multitarget and disease-modifying agents have a preventative impact on AD or mitigate symptoms in diagnosed patients. The pathological alterations of AD start 30 years before symptoms, and it is essential to develop the capacity to detect those changes. In this regard, molecular biomarkers that detect early pathological manifestations are helpful. Based on markers data, early preventive interventions could reduce more than 40% of AD cases. Protective actions include exercise, shown to induce neurogenesis, cognitive stimulation, intellectual-social activity, and nutrition among others. Mediterranean diet, preprobiotics, and nutraceuticals containing bioactive molecules with antioxidant and anti-inflammatory properties are relevant. Antiprotein aggregation molecules whose mechanisms were described are important. Anti-inflammatory agents with anti-aggregation properties that help to control cognitive impairment, include quercetin, biocurcumin, rosemarinic acid, and Andean shilajit. Anthocyanidins, e.g., delphinidin, malvidin, and natural flavonoids, are also included. Quercetin and hydroxy-tyrosol are antiaging molecules and could have anti-AD properties. We emphasize the relevance of nutraceuticals as a main actor in the prevention and/or control of dementia and particularly AD. View Full-Text
Keywords: AD prevention; interventional approaches toward Alzheimer´s treatment; nutraceutical compounds; mechanisms of action in AD therapy; bioactive molecules derived from plants in AD; vitamins and cofactors actions in AD AD prevention; interventional approaches toward Alzheimer´s treatment; nutraceutical compounds; mechanisms of action in AD therapy; bioactive molecules derived from plants in AD; vitamins and cofactors actions in AD
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MDPI and ACS Style

Maccioni, R.B.; Calfío, C.; González, A.; Lüttges, V. Novel Nutraceutical Compounds in Alzheimer Prevention. Biomolecules 2022, 12, 249. https://doi.org/10.3390/biom12020249

AMA Style

Maccioni RB, Calfío C, González A, Lüttges V. Novel Nutraceutical Compounds in Alzheimer Prevention. Biomolecules. 2022; 12(2):249. https://doi.org/10.3390/biom12020249

Chicago/Turabian Style

Maccioni, Ricardo B., Camila Calfío, Andrea González, and Valentina Lüttges. 2022. "Novel Nutraceutical Compounds in Alzheimer Prevention" Biomolecules 12, no. 2: 249. https://doi.org/10.3390/biom12020249

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