The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Study Design
2.2. Procedures
2.3. Assays
2.4. Sample Size
2.5. Statistical Workout
3. Results
3.1. Baseline Characteristics
3.2. Effects of Bariatric Surgery on Anthropometric, Biochemical Variables and cIMT
3.3. Effects of Bariatric Surgery on Inflammation and Endothelial Biomarkers
3.4. Ancyllary and Multivariate Analyses
4. Discussion
Limitations of the Study and Generalization
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Controls (n = 20) | SG (n = 20) | RYGB (n = 20) | |
---|---|---|---|
BMI (kg/m2) | 44.0 ± 5.4 | 45.0 ±6.9 | 43.7 ± 7.2 |
EBW (kg) | 59.4 ± 17.4 | 61.6 ± 21.2 | 56.7 ± 20.8 |
Hypertension (%) | 10 (50) | 10 (50) | 18 (90) †‡ |
Type 2 DM (%) | 8 (40) | 6 (30) | 10 (50) |
cIMT (mm) | 0.66 ± 0.10 | 0.65 ± 0.11 | 0.66 ± 0.13 |
Systolic BP (mmHg) | 145 ± 16 | 141 ± 17 | 144 ± 16 |
Diastolic BP (mmHg) | 87 ± 9 | 85 ± 11 | 87 ± 11 |
LDL (mmol/L) | 3.0 ± 0.8 | 3.0 ± 0.9 | 2.1 ± 0.8 †‡ |
HDL (mmol/L) | 1.1 ± 0.4 | 1.0 ± 0.2 | 1.0 ± 0.2 |
Glucose (mmol/L) | 6.6 ± 2.3 | 5.9 ± 1.9 | 7.2 ± 3.3 |
Insulin (mU/L) | 30 ± 16 | 19 ± 9 † | 21 ± 14 † |
HOMA-IR | 9.5 ± 8.0 | 5.1 ± 3.1 † | 6.4 ± 5.7 † |
Controls (n = 20) | SG (n = 20) | RYGB (n = 20) | |
---|---|---|---|
BMI (kg/m2) | 45.2 ±7.1 | 33.2 ± 4.1 *† | 31.6 ± 6.5 *† |
EBW (kg) | 3.7 ± 14.1 | 57.4 ± 18.2 *† | 69.4 ± 26.2 *† |
Hypertension (%) | 10 (50) | 1 (0.5) * | 7 (35) *‡ |
Type 2 DM (%) | 8 (40) | 4 (20) * | 2 (10) * |
cIMT (mm) | 0.67 ± 0.11 | 0.60 ± 0.09 *† | 0.60 ± 0.12 *† |
Systolic BP (mmHg) | 151 ± 12 | 130 ± 12 *† | 129 ± 17 *† |
Diastolic BP (mmHg) | 89 ± 8 | 84 ± 8 † | 76 ± 12 *† |
LDL (mmol/L) | 3.2 ± 0.6 | 2.9 ± 0.8 | 1.9 ± 0.7 |
HDL (mmol/L) | 1.0 ± 0.3 | 1.2 ± 0.2 *† | 1.2 ± 0.4 *† |
Glucose (mmol/L) | 7.0 ± 2.9 | 5.4 ± 0.9 † | 5.5 ± 1.7 *† |
Insulin (mU/L) | 27 ± 14 | 10 ± 6 *† | 7 ± 3 *† |
HOMA-IR | 15.2 ± 28.6 | 2.4 ± 1.6 | 3.2 ± 5.8 |
Δ cIMT | Δ TT | Δ FT | ||||
---|---|---|---|---|---|---|
r | p | r | p | r | p | |
Δ CRP | 0.317 | 0.014 | −0.444 | <0.001 | −0.259 | 0.046 |
Δ PAI-1 | 0.381 | 0.030 | −0.238 | 0.067 | −0.145 | 0.268 |
Δ sICAM-1 | 0.080 | 0.544 | −0.097 | 0.459 | −0.051 | 0.698 |
Δ sVCAM-1 | 0.045 | 0.736 | −0.189 | 0.149 | −0.014 | 0.914 |
Δ IL-6 | 0.156 | 0.234 | −0.024 | 0.855 | −0.105 | 0.424 |
Δ IL-18 | 0.261 | 0.056 | −0.333 | 0.014 | −0.271 | 0.048 |
Δ sTWEAK | −0.254 | 0.050 | 0.303 | 0.019 | 0.299 | 0.020 |
Δ TT | −0.428 | 0.010 | 1.000 | - | 0.849 | <0.001 |
Δ FT | −0.269 | 0.038 | 0.849 | <0.001 | 1.000 | - |
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Cobeta, P.; Pariente, R.; Osorio, A.; Marchan, M.; Blázquez, L.; Pestaña, D.; Galindo, J.; Botella-Carretero, J.I. The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men. Biomolecules 2022, 12, 1827. https://doi.org/10.3390/biom12121827
Cobeta P, Pariente R, Osorio A, Marchan M, Blázquez L, Pestaña D, Galindo J, Botella-Carretero JI. The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men. Biomolecules. 2022; 12(12):1827. https://doi.org/10.3390/biom12121827
Chicago/Turabian StyleCobeta, Pilar, Roberto Pariente, Alvaro Osorio, Marta Marchan, Luis Blázquez, David Pestaña, Julio Galindo, and José I. Botella-Carretero. 2022. "The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men" Biomolecules 12, no. 12: 1827. https://doi.org/10.3390/biom12121827