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Design and Synthesis of Novel Peptides to Protect Ferulic Acid against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin

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School of Food Science and Engineering, Yangzhou University, 196 Huayang West Road, Yangzhou 225127, China
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Department of Biological Functions Engineering, Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Kitakyushu Science and Research Park, Kitakyushu 8080196, Fukuoka, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Jose Manuel Lorenzo Rodriguez
Biomolecules 2021, 11(9), 1285; https://doi.org/10.3390/biom11091285
Received: 9 August 2021 / Revised: 23 August 2021 / Accepted: 24 August 2021 / Published: 27 August 2021
Ferulic acid (FA) is known for its excellent antioxidant properties, which can provide many health benefits. One of its drawbacks is its instability under UVA light, which limits its potency. In this study, the new peptides LW2 (QNKRFYFRKNQ) and CW2 (a cyclic form of LW2) were designed based on bovine serum albumin site IIA conformation. A UVA irradiation experiment was performed to investigate the protective ability of these peptides towards FA against UVA damage. The percentages of FA remaining under UV irradiation due to the protection of CW2 and LW2 were 83% and 76%, respectively. The results showed the importance of the cationic residues and hydrophobic residues included in the peptide sequences. Moreover, the cyclic rigid structure showed greater protective ability as compared to its linear counterpart. View Full-Text
Keywords: ferulic acid; UVA light; cyclic peptide; bovine serum albumin ferulic acid; UVA light; cyclic peptide; bovine serum albumin
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MDPI and ACS Style

Wu, Y.; Farrag, H.N.; Kato, T.; Li, H.; Ikeno, S. Design and Synthesis of Novel Peptides to Protect Ferulic Acid against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin. Biomolecules 2021, 11, 1285. https://doi.org/10.3390/biom11091285

AMA Style

Wu Y, Farrag HN, Kato T, Li H, Ikeno S. Design and Synthesis of Novel Peptides to Protect Ferulic Acid against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin. Biomolecules. 2021; 11(9):1285. https://doi.org/10.3390/biom11091285

Chicago/Turabian Style

Wu, Yinghan, Hisham N. Farrag, Tamaki Kato, Hua Li, and Shinya Ikeno. 2021. "Design and Synthesis of Novel Peptides to Protect Ferulic Acid against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin" Biomolecules 11, no. 9: 1285. https://doi.org/10.3390/biom11091285

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