Next Article in Journal
Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma
Previous Article in Journal
TRPV Protein Family—From Mechanosensing to Cancer Invasion
biomolecules-logo
Article Menu

Article Menu

Opinion

COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street?

1
PanTherapeutics, CH 1095 Lutry, Switzerland
2
Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Purba Medinipur 721172, India
3
Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
4
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
5
Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8397, Japan
6
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, P.O. Box 566, Irbid 21163, Jordan
7
Zoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt
8
Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
9
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55902, USA
10
Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
11
Department of Food Science, University of Otago, Dunedin 9054, New Zealand
12
School of Engineering and Sciences, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Monterrey 64849, Mexico
13
Department of Environmental Health Sciences, Tulane University, New Orleans, LA 70112, USA
14
Department of Zoology, Patna University, Patna 800005, India
15
Research Center for Immunodeficiency, Children’s Medical Center, Tehran University of Medical Sciences, Tehran 1416753955, Iran
16
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), 17177 Stockholm, Sweden
17
Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain
18
Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, LA 70112, USA
19
Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram 721140, India
20
Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, 75120 Uppsala, Sweden
21
Applied Statistics Unit, Indian Statistical Institute, Kolkata 700108, India
22
Italian Agency for Development Cooperation—Khartoum, Sudan Street 33, Al Amarat 11111, Sudan
23
Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad 500007, India
24
Department of Biochemistry, Kakatiya Medical College, Warangal 506007, India
25
Translational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, Brazil
26
Mads Clausen Institute, University of Southern Denmark, NanoSYD, Alsion 2, 6400 Sønderborg, Denmark
27
Department of Molecular Medicine, University of Padova, 35122 Padova, PD, Italy
28
UPMC Hillman Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
29
School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, UK
30
Department of Molecular Medicine and USF Health Byrd Alzheimer’s Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Moriya Tsuji
Biomolecules 2021, 11(7), 1020; https://doi.org/10.3390/biom11071020
Received: 21 June 2021 / Revised: 8 July 2021 / Accepted: 10 July 2021 / Published: 13 July 2021
Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines. View Full-Text
Keywords: COVID-19; vaccines; SARS-CoV-2; thrombosis; chronic smokers COVID-19; vaccines; SARS-CoV-2; thrombosis; chronic smokers
Show Figures

Figure 1

MDPI and ACS Style

Lundstrom, K.; Barh, D.; Uhal, B.D.; Takayama, K.; Aljabali, A.A.A.; Abd El-Aziz, T.M.; Lal, A.; Redwan, E.M.; Adadi, P.; Chauhan, G.; Sherchan, S.P.; Azad, G.K.; Rezaei, N.; Serrano-Aroca, Á.; Bazan, N.G.; Hassan, S.S.; Panda, P.K.; Pal Choudhury, P.; Pizzol, D.; Kandimalla, R.; Baetas-da-Cruz, W.; Mishra, Y.K.; Palu, G.; Brufsky, A.M.; Tambuwala, M.M.; Uversky, V.N. COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street? Biomolecules 2021, 11, 1020. https://doi.org/10.3390/biom11071020

AMA Style

Lundstrom K, Barh D, Uhal BD, Takayama K, Aljabali AAA, Abd El-Aziz TM, Lal A, Redwan EM, Adadi P, Chauhan G, Sherchan SP, Azad GK, Rezaei N, Serrano-Aroca Á, Bazan NG, Hassan SS, Panda PK, Pal Choudhury P, Pizzol D, Kandimalla R, Baetas-da-Cruz W, Mishra YK, Palu G, Brufsky AM, Tambuwala MM, Uversky VN. COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street? Biomolecules. 2021; 11(7):1020. https://doi.org/10.3390/biom11071020

Chicago/Turabian Style

Lundstrom, Kenneth, Debmalya Barh, Bruce D. Uhal, Kazuo Takayama, Alaa A.A. Aljabali, Tarek M. Abd El-Aziz, Amos Lal, Elrashdy M. Redwan, Parise Adadi, Gaurav Chauhan, Samendra P. Sherchan, Gajendra K. Azad, Nima Rezaei, Ángel Serrano-Aroca, Nicolas G. Bazan, Sk S. Hassan, Pritam K. Panda, Pabitra Pal Choudhury, Damiano Pizzol, Ramesh Kandimalla, Wagner Baetas-da-Cruz, Yogendra K. Mishra, Giorgio Palu, Adam M. Brufsky, Murtaza M. Tambuwala, and Vladimir N. Uversky 2021. "COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street?" Biomolecules 11, no. 7: 1020. https://doi.org/10.3390/biom11071020

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop