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Article

Molecular Targets and Biological Functions of cAMP Signaling in Arabidopsis

1
School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China
2
Zhengzhou Research Base, State Key Laboratory of Cotton Biology, Zhengzhou University, Zhengzhou 450001, China
*
Author to whom correspondence should be addressed.
Academic Editor: Mark S. Johnson
Biomolecules 2021, 11(5), 688; https://doi.org/10.3390/biom11050688
Received: 25 March 2021 / Revised: 29 April 2021 / Accepted: 30 April 2021 / Published: 3 May 2021
(This article belongs to the Collection Molecular Biology: Feature Papers)
Cyclic AMP (cAMP) is a pivotal signaling molecule existing in almost all living organisms. However, the mechanism of cAMP signaling in plants remains very poorly understood. Here, we employ the engineered activity of soluble adenylate cyclase to induce cellular cAMP elevation in Arabidopsis thaliana plants and identify 427 cAMP-responsive genes (CRGs) through RNA-seq analysis. Induction of cellular cAMP elevation inhibits seed germination, disturbs phytohormone contents, promotes leaf senescence, impairs ethylene response, and compromises salt stress tolerance and pathogen resistance. A set of 62 transcription factors are among the CRGs, supporting a prominent role of cAMP in transcriptional regulation. The CRGs are significantly overrepresented in the pathways of plant hormone signal transduction, MAPK signaling, and diterpenoid biosynthesis, but they are also implicated in lipid, sugar, K+, nitrate signaling, and beyond. Our results provide a basic framework of cAMP signaling for the community to explore. The regulatory roles of cAMP signaling in plant plasticity are discussed. View Full-Text
Keywords: Arabidopsis thaliana; cyclic AMP; signaling; mechanism; function; regulation; adenylate cyclase Arabidopsis thaliana; cyclic AMP; signaling; mechanism; function; regulation; adenylate cyclase
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MDPI and ACS Style

Xu, R.; Guo, Y.; Peng, S.; Liu, J.; Li, P.; Jia, W.; Zhao, J. Molecular Targets and Biological Functions of cAMP Signaling in Arabidopsis. Biomolecules 2021, 11, 688. https://doi.org/10.3390/biom11050688

AMA Style

Xu R, Guo Y, Peng S, Liu J, Li P, Jia W, Zhao J. Molecular Targets and Biological Functions of cAMP Signaling in Arabidopsis. Biomolecules. 2021; 11(5):688. https://doi.org/10.3390/biom11050688

Chicago/Turabian Style

Xu, Ruqiang, Yanhui Guo, Song Peng, Jinrui Liu, Panyu Li, Wenjing Jia, and Junheng Zhao. 2021. "Molecular Targets and Biological Functions of cAMP Signaling in Arabidopsis" Biomolecules 11, no. 5: 688. https://doi.org/10.3390/biom11050688

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