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Review

The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models

1
Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Gurgaon-Faridabad Ex-pressway, Faridabad 121001, India
2
IRD, AP-HM, SSA, VITROME, Aix-Marseille University, 13385 Marseille, France
3
Institut Hospitalo Universitaire Méditerranée Infection, 13385 Marseille, France
4
TechnoJouvence, 13385 Marseille, France
*
Author to whom correspondence should be addressed.
Academic Editors: Anna Rita Franco Migliaccio and Alessandra Salvetti
Biomolecules 2021, 11(5), 667; https://doi.org/10.3390/biom11050667
Received: 27 February 2021 / Revised: 2 April 2021 / Accepted: 9 April 2021 / Published: 30 April 2021
(This article belongs to the Special Issue New Insights into Stem Cell Regulation)
Adult stem cells (ASCs) are the undifferentiated cells that possess self-renewal and differentiation abilities. They are present in all major organ systems of the body and are uniquely reserved there during development for tissue maintenance during homeostasis, injury, and infection. They do so by promptly modulating the dynamics of proliferation, differentiation, survival, and migration. Any imbalance in these processes may result in regeneration failure or developing cancer. Hence, the dynamics of these various behaviors of ASCs need to always be precisely controlled. Several genetic and epigenetic factors have been demonstrated to be involved in tightly regulating the proliferation, differentiation, and self-renewal of ASCs. Understanding these mechanisms is of great importance, given the role of stem cells in regenerative medicine. Investigations on various animal models have played a significant part in enriching our knowledge and giving In Vivo in-sight into such ASCs regulatory mechanisms. In this review, we have discussed the recent In Vivo studies demonstrating the role of various genetic factors in regulating dynamics of different ASCs viz. intestinal stem cells (ISCs), neural stem cells (NSCs), hematopoietic stem cells (HSCs), and epidermal stem cells (Ep-SCs). View Full-Text
Keywords: adult stem cell; signaling pathway; animal model; intestinal stem cell; neural stem cell; hematopoietic stem cell; epidermal stem cell adult stem cell; signaling pathway; animal model; intestinal stem cell; neural stem cell; hematopoietic stem cell; epidermal stem cell
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MDPI and ACS Style

Krishnan, M.; Kumar, S.; Kangale, L.J.; Ghigo, E.; Abnave, P. The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models. Biomolecules 2021, 11, 667. https://doi.org/10.3390/biom11050667

AMA Style

Krishnan M, Kumar S, Kangale LJ, Ghigo E, Abnave P. The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models. Biomolecules. 2021; 11(5):667. https://doi.org/10.3390/biom11050667

Chicago/Turabian Style

Krishnan, Meera; Kumar, Sahil; Kangale, Luis J.; Ghigo, Eric; Abnave, Prasad. 2021. "The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models" Biomolecules 11, no. 5: 667. https://doi.org/10.3390/biom11050667

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