Next Article in Journal
Green Biosynthesis of Silver Nanoparticles Using Leaf Extract of Carissa carandas L. and Their Antioxidant and Antimicrobial Activity against Human Pathogenic Bacteria
Next Article in Special Issue
Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery
Previous Article in Journal
Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages
Previous Article in Special Issue
Discovery and Characterization of an ALFA-Tag-Specific Affinity Resin Optimized for Protein Purification at Low Temperatures in Physiological Buffer
Review

Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies

1
Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark
2
Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Nick Devoogdt
Biomolecules 2021, 11(2), 298; https://doi.org/10.3390/biom11020298
Received: 7 January 2021 / Revised: 10 February 2021 / Accepted: 11 February 2021 / Published: 17 February 2021
(This article belongs to the Special Issue The Therapeutic and Diagnostic Potential of Nanobodies)
The complement system is part of the innate immune response, where it provides immediate protection from infectious agents and plays a fundamental role in homeostasis. Complement dysregulation occurs in several diseases, where the tightly regulated proteolytic cascade turns offensive. Prominent examples are atypical hemolytic uremic syndrome, paroxysmal nocturnal hemoglobinuria and Alzheimer’s disease. Therapeutic intervention targeting complement activation may allow treatment of such debilitating diseases. In this review, we describe a panel of complement targeting nanobodies that allow modulation at different steps of the proteolytic cascade, from the activation of the C1 complex in the classical pathway to formation of the C5 convertase in the terminal pathway. Thorough structural and functional characterization has provided a deep mechanistic understanding of the mode of inhibition for each of the nanobodies. These complement specific nanobodies are novel powerful probes for basic research and offer new opportunities for in vivo complement modulation. View Full-Text
Keywords: complement system; proteolytic cascade; convertase; inhibitor; structural biology; molecular mechanism complement system; proteolytic cascade; convertase; inhibitor; structural biology; molecular mechanism
Show Figures

Figure 1

MDPI and ACS Style

Zarantonello, A.; Pedersen, H.; Laursen, N.S.; Andersen, G.R. Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies. Biomolecules 2021, 11, 298. https://doi.org/10.3390/biom11020298

AMA Style

Zarantonello A, Pedersen H, Laursen NS, Andersen GR. Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies. Biomolecules. 2021; 11(2):298. https://doi.org/10.3390/biom11020298

Chicago/Turabian Style

Zarantonello, Alessandra, Henrik Pedersen, Nick S. Laursen, and Gregers R. Andersen 2021. "Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies" Biomolecules 11, no. 2: 298. https://doi.org/10.3390/biom11020298

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop