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Article

Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients

Department of Internal Medicine, School of Medical Sciences, State University of Campinas, Campinas 13083-970, São Paulo, Brazil
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Academic Editors: Amarylis Claudine Bonito A. Wanschel, Ana Iochabel Soares Moretti and Alessandro Gonzalez Salerno
Biomolecules 2021, 11(12), 1840; https://doi.org/10.3390/biom11121840
Received: 16 November 2021 / Revised: 2 December 2021 / Accepted: 2 December 2021 / Published: 7 December 2021
Aim: Hypertension is a strong risk factor for atherosclerosis. Increased carotid intima-media thickness (cIMT) and carotid plaques are considered subclinical markers of atherosclerosis. This study aimed at evaluating the serum expression of miRNAs previously related to adverse vascular remodeling and correlating them with carotid plaques and cIMT in hypertensive patients. Methods: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR-145-5p, miR-let7c, miR-92a, miR-30a and miR-451 in 177 hypertensive patients. Carotid plaques and cIMT were evaluated by ultrasound, and the expression of selected miRNAs was evaluated by a quantitative polymerase chain reaction. Results: Among all participants (age = 60.6 ± 10.7 years, 43% males), there were 59% with carotid plaques. We observed an increased expression of miR-145-5p (Fold Change = 2.0, p = 0.035) and miR-let7c (Fold Change = 3.8, p = 0.045) in participants with atherosclerotic plaque when compared to those without plaque. In the logistic regression analysis adjusted for relevant covariates, these miRNAs showed a stronger association with carotid plaques (miR-145-5p: Beta ± SE = 0.050 ± 0.020, p = 0.016 and miR-let7c: Beta ± SE = 0.056 ± 0.019, p = 0.003). Conclusions: Hypertensive patients with carotid plaques have an increased expression of miR-145-5p and miR-let7c, suggesting a potential role of these miRNAs as a biomarker for subclinical atherosclerosis in hypertensive individuals. View Full-Text
Keywords: hypertension; carotid atherosclerosis; miRNAs hypertension; carotid atherosclerosis; miRNAs
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MDPI and ACS Style

Minin, E.O.Z.; Paim, L.R.; Lopes, E.C.P.; Bueno, L.C.M.; Carvalho-Romano, L.F.R.S.; Marques, E.R.; Vegian, C.F.L.; Pio-Magalhães, J.A.; Coelho-Filho, O.R.; Sposito, A.C.; Matos-Souza, J.R.; Nadruz, W.; Schreiber, R. Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients. Biomolecules 2021, 11, 1840. https://doi.org/10.3390/biom11121840

AMA Style

Minin EOZ, Paim LR, Lopes ECP, Bueno LCM, Carvalho-Romano LFRS, Marques ER, Vegian CFL, Pio-Magalhães JA, Coelho-Filho OR, Sposito AC, Matos-Souza JR, Nadruz W, Schreiber R. Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients. Biomolecules. 2021; 11(12):1840. https://doi.org/10.3390/biom11121840

Chicago/Turabian Style

Minin, Eduarda O.Z., Layde R. Paim, Elisangela C.P. Lopes, Larissa C.M. Bueno, Luís F.R.S. Carvalho-Romano, Edmilson R. Marques, Camila F.L. Vegian, José A. Pio-Magalhães, Otavio R. Coelho-Filho, Andrei C. Sposito, José R. Matos-Souza, Wilson Nadruz, and Roberto Schreiber. 2021. "Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients" Biomolecules 11, no. 12: 1840. https://doi.org/10.3390/biom11121840

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