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Review

Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis

1
Department of Biochemistry, AIIMS, Kalyani 741245, West Bengal, India
2
Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Maharishi Markandeshwar University (MMU), Mullana, Ambala 133207, Haryana, India
3
Department of Zoology, DAV University, Jalandhar 144012, Punjab, India
4
Neuroimmunology Unit, IRCSS Fondazione Santa Lucia, 00143 Rome, Italy
5
Department of Laboratory Medicine, Research and Development Division, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, 00186 Rome, Italy
6
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy
*
Authors to whom correspondence should be addressed.
Co-first authors.
Academic Editors: Marcus O. W. Grimm and Nela Pivac
Biomolecules 2021, 11(11), 1598; https://doi.org/10.3390/biom11111598
Received: 5 June 2021 / Revised: 9 October 2021 / Accepted: 22 October 2021 / Published: 28 October 2021
(This article belongs to the Collection Feature Papers in Section Molecular Medicine)
Evidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD. View Full-Text
Keywords: astrocyte; microglia; copper; Alzheimer’s disease astrocyte; microglia; copper; Alzheimer’s disease
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MDPI and ACS Style

Pal, A.; Rani, I.; Pawar, A.; Picozza, M.; Rongioletti, M.; Squitti, R. Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis. Biomolecules 2021, 11, 1598. https://doi.org/10.3390/biom11111598

AMA Style

Pal A, Rani I, Pawar A, Picozza M, Rongioletti M, Squitti R. Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis. Biomolecules. 2021; 11(11):1598. https://doi.org/10.3390/biom11111598

Chicago/Turabian Style

Pal, Amit, Isha Rani, Anil Pawar, Mario Picozza, Mauro Rongioletti, and Rosanna Squitti. 2021. "Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis" Biomolecules 11, no. 11: 1598. https://doi.org/10.3390/biom11111598

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