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Review

Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance

by 1 and 2,*
1
Department of Internal Medicine, Kralovske Vinohrady University Hospital and Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic
2
Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Piotr Ceranowicz
Biomolecules 2021, 11(10), 1414; https://doi.org/10.3390/biom11101414
Received: 21 August 2021 / Revised: 21 September 2021 / Accepted: 23 September 2021 / Published: 28 September 2021
The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the human host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet is the major source of the substrates that are metabolized to end-products, further serving as signal molecules in the microbiota-host cross-talk. Among these signal molecules, branched-chain amino acids (BCAAs) has gained significant scientific attention. BCAAs are abundant in animal-based dietary sources; they are both produced and degraded by gut microbiota and the host circulating levels are associated with the risk of type 2 diabetes. This review aims to summarize the current knowledge on the complex relationship between gut microbiota and its functional capacity to handle BCAAs as well as the host BCAA metabolism in insulin resistance development. Targeting gut microbiota BCAA metabolism with a dietary modulation could represent a promising approach in the prevention and treatment of insulin resistance related states, such as obesity and diabetes. View Full-Text
Keywords: branched-chain amino acids; insulin resistance; type 2 diabetes; gut microbiome; gut metabolome branched-chain amino acids; insulin resistance; type 2 diabetes; gut microbiome; gut metabolome
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MDPI and ACS Style

Gojda, J.; Cahova, M. Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance. Biomolecules 2021, 11, 1414. https://doi.org/10.3390/biom11101414

AMA Style

Gojda J, Cahova M. Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance. Biomolecules. 2021; 11(10):1414. https://doi.org/10.3390/biom11101414

Chicago/Turabian Style

Gojda, Jan, and Monika Cahova. 2021. "Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance" Biomolecules 11, no. 10: 1414. https://doi.org/10.3390/biom11101414

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