The Role of the Unfolded Protein Response on Renal Lipogenesis in C57BL/6 Mice
, Lilia G. Noriega 3, Carlos Pérez-Monter 4, Gabriela Alemán 3, Rogelio Hernández-Pando 5, Ricardo Correa-Rotter 2, Victoria RamÃrez 6, Armando R. Tovar 3, Iván Torre-Villalvazo 3,* and Claudia Tovar-Palacio 7,*
Round 1
Reviewer 1 Report
In this manuscript, Figueroa-Juarez and colleagues evaluated the impact of ER stress stimulation in kidney lipogenesis, by using C57BL/6 mice a model. Overall, this is an interesting and well-written manuscript. Experiments are well designed and results are clear, consistent, and well discussed. The final discussion of results is extensive and well contextualized.
However, results shown in figure 2 must include a control (vehicle-treated mice)
Author Response
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Author Response File: 
Author Response.pdf
Reviewer 2 Report
I recommend publication of this article. The authors make interesting observations regarding induction of ER stress and pathological alterations in the kidney of mice treated with tunicamycin. The only correction I would like to be made is to add untreated control panels (C) to Fig 2 (Only 8 h and 24h treated panels are presented).
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
The authors provided the missing control and generated a new complete figure. Therefore, I now recommend the publication of the manuscript in Biomolecules
