Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays
Abstract
:1. Introduction
2. RT-QuIC Assays as Diagnostic Tools
2.1. Tau
2.2. αSynuclein
3. Application of RT-QuIC Assays to Understand Characteristics of Protein Seeds
Exploiting Strains for Diagnosis and Dissecting Disease-Related Mechanisms
4. Defining Protein Seed Distributions and Networks
4.1. Seeding Activity Assessments of Prion Propagation and Transmission
4.2. The Networks of Tau and αSyn Seeds
5. RT-QuIC Assays to Determine the Structural Modalities of Seeds and to Test Anti-amyloid Drugs and Disinfectants
Advantages, Limitations, and Further Development of RT-QuIC Assays
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Manca, M.; Kraus, A. Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays. Biomolecules 2020, 10, 1233. https://doi.org/10.3390/biom10091233
Manca M, Kraus A. Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays. Biomolecules. 2020; 10(9):1233. https://doi.org/10.3390/biom10091233
Chicago/Turabian StyleManca, Matteo, and Allison Kraus. 2020. "Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays" Biomolecules 10, no. 9: 1233. https://doi.org/10.3390/biom10091233
APA StyleManca, M., & Kraus, A. (2020). Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays. Biomolecules, 10(9), 1233. https://doi.org/10.3390/biom10091233