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Role of Antioxidants in Alleviating Bisphenol A Toxicity

Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do 17546, Korea
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(8), 1105; https://doi.org/10.3390/biom10081105
Received: 23 June 2020 / Revised: 16 July 2020 / Accepted: 22 July 2020 / Published: 25 July 2020
(This article belongs to the Section Molecular Medicine)
Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA-induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA-associated stress. We summarize the current knowledge on the biological function of enzymatic and non-enzymatic antioxidants, and discuss their practical potential as BPA-detoxifying agents. View Full-Text
Keywords: bisphenol A; antioxidants; diseases; stress; endocrine disruptors bisphenol A; antioxidants; diseases; stress; endocrine disruptors
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MDPI and ACS Style

Amjad, S.; Rahman, M.S.; Pang, M.-G. Role of Antioxidants in Alleviating Bisphenol A Toxicity. Biomolecules 2020, 10, 1105. https://doi.org/10.3390/biom10081105

AMA Style

Amjad S, Rahman MS, Pang M-G. Role of Antioxidants in Alleviating Bisphenol A Toxicity. Biomolecules. 2020; 10(8):1105. https://doi.org/10.3390/biom10081105

Chicago/Turabian Style

Amjad, Shehreen; Rahman, Md S.; Pang, Myung-Geol. 2020. "Role of Antioxidants in Alleviating Bisphenol A Toxicity" Biomolecules 10, no. 8: 1105. https://doi.org/10.3390/biom10081105

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