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Article

Isoprostanoid Profiling of Marine Microalgae

1
Institut des Biomolécules Max Mousseron, IBMM, Université de Montpellier, CNRS, ENSCM, Faculté de Pharmacie, 34093 CEDEX 5 Montpellier, France
2
Integrative Biology of Marine Models, LBI2M (Sorbonne Université/CNRS), Station Biologique de Roscoff (SBR), 29680 Roscoff, France
3
Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, YO10 5DD York, UK
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(7), 1073; https://doi.org/10.3390/biom10071073
Received: 5 June 2020 / Revised: 9 July 2020 / Accepted: 14 July 2020 / Published: 18 July 2020
(This article belongs to the Special Issue Lipids of Marine Algae)
Algae result from a complex evolutionary history that shapes their metabolic network. For example, these organisms can synthesize different polyunsaturated fatty acids, such as those found in land plants and oily fish. Due to the presence of numerous double-bonds, such molecules can be oxidized nonenzymatically, and this results in the biosynthesis of high-value bioactive metabolites named isoprostanoids. So far, there have been only a few studies reporting isoprostanoid productions in algae. To fill this gap, the current investigation aimed at profiling isoprostanoids by liquid chromatography -mass spectrometry/mass spectrometry (LC-MS/MS) in four marine microalgae. A good correlation was observed between the most abundant polyunsaturated fatty acids (PUFAs) produced by the investigated microalgal species and their isoprostanoid profiles. No significant variations in the content of oxidized derivatives were observed for Rhodomonas salina and Chaetoceros gracilis under copper stress, whereas increases in the production of C18-, C20- and C22-derived isoprostanoids were monitored in Tisochrysis lutea and Phaeodactylum tricornutum. In the presence of hydrogen peroxide, no significant changes were observed for C. gracilis and for T. lutea, while variations were monitored for the other two algae. This study paves the way to further studying the physiological roles of isoprostanoids in marine microalgae and exploring these organisms as bioresources for isoprostanoid production. View Full-Text
Keywords: microalgae; PUFAs; isoprostanoids; oxidative stress; micro-LC-MS/MS microalgae; PUFAs; isoprostanoids; oxidative stress; micro-LC-MS/MS
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MDPI and ACS Style

Vigor, C.; Oger, C.; Reversat, G.; Rocher, A.; Zhou, B.; Linares-Maurizi, A.; Guy, A.; Bultel-Poncé, V.; Galano, J.-M.; Vercauteren, J.; Durand, T.; Potin, P.; Tonon, T.; Leblanc, C. Isoprostanoid Profiling of Marine Microalgae. Biomolecules 2020, 10, 1073. https://doi.org/10.3390/biom10071073

AMA Style

Vigor C, Oger C, Reversat G, Rocher A, Zhou B, Linares-Maurizi A, Guy A, Bultel-Poncé V, Galano J-M, Vercauteren J, Durand T, Potin P, Tonon T, Leblanc C. Isoprostanoid Profiling of Marine Microalgae. Biomolecules. 2020; 10(7):1073. https://doi.org/10.3390/biom10071073

Chicago/Turabian Style

Vigor, Claire; Oger, Camille; Reversat, Guillaume; Rocher, Amandine; Zhou, Bingqing; Linares-Maurizi, Amandyne; Guy, Alexandre; Bultel-Poncé, Valérie; Galano, Jean-Marie; Vercauteren, Joseph; Durand, Thierry; Potin, Philippe; Tonon, Thierry; Leblanc, Catherine. 2020. "Isoprostanoid Profiling of Marine Microalgae" Biomolecules 10, no. 7: 1073. https://doi.org/10.3390/biom10071073

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