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Review

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

1
Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, Italy
2
Institute of Biosciences and BioResources (IBBR), National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
3
Institute of Biochemistry and Cell Biology (IBBC), National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(7), 1007; https://doi.org/10.3390/biom10071007
Received: 12 June 2020 / Revised: 25 June 2020 / Accepted: 28 June 2020 / Published: 7 July 2020
Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea. View Full-Text
Keywords: marine organisms; antiviral; marine natural products; viruses marine organisms; antiviral; marine natural products; viruses
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MDPI and ACS Style

Riccio, G.; Ruocco, N.; Mutalipassi, M.; Costantini, M.; Zupo, V.; Coppola, D.; de Pascale, D.; Lauritano, C. Ten-Year Research Update Review: Antiviral Activities from Marine Organisms. Biomolecules 2020, 10, 1007. https://doi.org/10.3390/biom10071007

AMA Style

Riccio G, Ruocco N, Mutalipassi M, Costantini M, Zupo V, Coppola D, de Pascale D, Lauritano C. Ten-Year Research Update Review: Antiviral Activities from Marine Organisms. Biomolecules. 2020; 10(7):1007. https://doi.org/10.3390/biom10071007

Chicago/Turabian Style

Riccio, Gennaro, Nadia Ruocco, Mirko Mutalipassi, Maria Costantini, Valerio Zupo, Daniela Coppola, Donatella de Pascale, and Chiara Lauritano. 2020. "Ten-Year Research Update Review: Antiviral Activities from Marine Organisms" Biomolecules 10, no. 7: 1007. https://doi.org/10.3390/biom10071007

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