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NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

1
Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
2
Instituto Teófilo Hernando y Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain
3
Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, 28006 Madrid, Spain
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 904; https://doi.org/10.3390/biom10060904
Received: 6 May 2020 / Revised: 3 June 2020 / Accepted: 9 June 2020 / Published: 14 June 2020
NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases. View Full-Text
Keywords: NRF2–ARE pathway; neurodegenerative diseases; oxidative stress; KEAP1; NRF2 regulation NRF2–ARE pathway; neurodegenerative diseases; oxidative stress; KEAP1; NRF2 regulation
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Cores, Á.; Piquero, M.; Villacampa, M.; León, R.; Menéndez, J.C. NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases. Biomolecules 2020, 10, 904.

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