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p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction

Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan
Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
Department of Molecular Aging Research, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 462;
Received: 30 January 2020 / Revised: 13 March 2020 / Accepted: 15 March 2020 / Published: 17 March 2020
(This article belongs to the Special Issue Deciphering alternative functions of the INK4a/ARF locus)
Senescent cells accumulate in tissues during aging or pathological settings. The semi-genetic or pharmacological targeting of senescent cells revealed that cellular senescence underlies many aspects of the aging-associated phenotype and diseases. We previously reported that cellular senescence contributes to aging- and disease-associated pulmonary dysfunction. We herein report that the elimination of Arf-expressing cells ameliorates cigarette smoke-induced lung pathologies in mice. Cigarette smoke induced the expression of Ink4a and Arf in lung tissue with concomitant increases in lung tissue compliance and alveolar airspace. The elimination of Arf-expressing cells prior to cigarette smoke exposure protected against these changes. Furthermore, the administration of cigarette smoke extract lead to pulmonary dysfunction, which was ameliorated by subsequent senescent cell elimination. Collectively, these results suggest that senescent cells are a potential therapeutic target for cigarette smoking-associated lung disease. View Full-Text
Keywords: p19Arf; senescence; senolysis; emphysema; COPD p19Arf; senescence; senolysis; emphysema; COPD
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MDPI and ACS Style

Mikawa, R.; Sato, T.; Suzuki, Y.; Baskoro, H.; Kawaguchi, K.; Sugimoto, M. p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction. Biomolecules 2020, 10, 462.

AMA Style

Mikawa R, Sato T, Suzuki Y, Baskoro H, Kawaguchi K, Sugimoto M. p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction. Biomolecules. 2020; 10(3):462.

Chicago/Turabian Style

Mikawa, Ryuta, Tadashi Sato, Yohei Suzuki, Hario Baskoro, Koichiro Kawaguchi, and Masataka Sugimoto. 2020. "p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction" Biomolecules 10, no. 3: 462.

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