Role of p53 in the Regulation of Cellular Senescence
1
Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
2
Department of Medical Biotechnologies, University of Siena, 67100 Siena, Italy
3
Department of Life, Health and Environmental Sciences, University of L’Aquila, 53100 L’Aquila, Italy
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 420; https://doi.org/10.3390/biom10030420
Received: 31 January 2020
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Revised: 4 March 2020
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Accepted: 5 March 2020
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Published: 8 March 2020
(This article belongs to the Special Issue Recent Advances in p53)
The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle arrest that has a crucial role in aging, and it also represents a robust physiological antitumor response, which counteracts oncogenic insults. In addition, senescent cells can also negatively impact the surrounding tissue microenvironment and the neighboring cells by secreting pro-inflammatory cytokines, ultimately triggering tissue dysfunction and/or unfavorable outcomes. This review focuses on the characteristics of senescence and on the recent advances in the contribution of p53 to cellular senescence. Moreover, we also discuss the p53-mediated regulation of several pathophysiological microenvironments that could be associated with senescence and its development.
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Keywords:
p53; senescence; cell cycle arrest; microenvironment; DNA damage
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MDPI and ACS Style
Mijit, M.; Caracciolo, V.; Melillo, A.; Amicarelli, F.; Giordano, A. Role of p53 in the Regulation of Cellular Senescence. Biomolecules 2020, 10, 420. https://doi.org/10.3390/biom10030420
AMA Style
Mijit M, Caracciolo V, Melillo A, Amicarelli F, Giordano A. Role of p53 in the Regulation of Cellular Senescence. Biomolecules. 2020; 10(3):420. https://doi.org/10.3390/biom10030420
Chicago/Turabian StyleMijit, Mahmut, Valentina Caracciolo, Antonio Melillo, Fernanda Amicarelli, and Antonio Giordano. 2020. "Role of p53 in the Regulation of Cellular Senescence" Biomolecules 10, no. 3: 420. https://doi.org/10.3390/biom10030420
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