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Open AccessReview

The Role of Urocortins in Intracerebral Hemorrhage

1
Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh 42300, Malaysia
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Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
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Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
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Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan
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College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA
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Department of Basic Sciences and Oral Biology, Faculty of Dentistry, Universiti Sains Islam Malaysia, Nilai 71800, Malaysia
7
Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Zhong-yang Road, Hualien 970, Taiwan
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CardioVascular Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan
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Institute of Medical Sciences, Tzu Chi University, Hualien 970, Taiwan
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PhD Program in Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan
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Neuro-Medical Scientific Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 96; https://doi.org/10.3390/biom10010096
Received: 6 November 2019 / Revised: 31 December 2019 / Accepted: 2 January 2020 / Published: 7 January 2020
Intracerebral hemorrhage (ICH) causes an accumulation of blood in the brain parenchyma that disrupts the normal neurological function of the brain. Despite extensive clinical trials, no medical or surgical therapy has shown to be effective in managing ICH, resulting in a poor prognosis for the patients. Urocortin (UCN) is a 40-amino-acid endogenous neuropeptide that belongs to the corticotropin-releasing hormone (CRH) family. The effect of UCN is activated by binding to two G-protein coupled receptors, CRH-R1 and CRH-R2, which are expressed in brain neurons and glial cells in various brain regions. Current research has shown that UCN exerts neuroprotective effects in ICH models via anti-inflammatory effects, which generally reduced brain edema and reduced blood-brain barrier disruption. These effects gradually help in the improvement of the neurological outcome, and thus, UCN may be a potential therapeutic target in the treatment of ICH. This review summarizes the data published to date on the role of UCN in ICH and the possible protective mechanisms underlined. View Full-Text
Keywords: corticotropin-releasing hormone receptor; endogenous neuropeptide; intracerebral hemorrhage; neuroprotective; urocortin corticotropin-releasing hormone receptor; endogenous neuropeptide; intracerebral hemorrhage; neuroprotective; urocortin
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MDPI and ACS Style

Choy, K.W.; Tsai, A. .-Y.; Lin, P. .-C.; Wu, M.-Y.; Lee, C.; Alias, A.; Pang, C.-Y.; Liew, H.-K. The Role of Urocortins in Intracerebral Hemorrhage. Biomolecules 2020, 10, 96.

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