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Review

High-Throughput Direct Mass Spectrometry-Based Metabolomics to Characterize Metabolite Fingerprints Associated with Alzheimer’s Disease Pathogenesis

1
Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain
2
International Campus of Excellence ceiA3, University of Huelva, 21007 Huelva, Spain
3
Biomarkers & Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Metabolites 2018, 8(3), 52; https://doi.org/10.3390/metabo8030052
Received: 23 August 2018 / Revised: 8 September 2018 / Accepted: 14 September 2018 / Published: 18 September 2018
(This article belongs to the Special Issue Metabolomics in Neurodegenerative Disease)
Direct mass spectrometry-based metabolomics has been widely employed in recent years to characterize the metabolic alterations underlying Alzheimer’s disease development and progression. This high-throughput approach presents great potential for fast and simultaneous fingerprinting of a vast number of metabolites, which can be applied to multiple biological matrices including serum/plasma, urine, cerebrospinal fluid and tissues. In this review article, we present the main advantages and drawbacks of metabolomics based on direct mass spectrometry compared with conventional analytical techniques, and provide a comprehensive revision of the literature on the use of these tools in the investigation of Alzheimer’s disease. View Full-Text
Keywords: metabolomics; direct mass spectrometry; Alzheimer’s disease; pathogenesis; biomarkers metabolomics; direct mass spectrometry; Alzheimer’s disease; pathogenesis; biomarkers
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MDPI and ACS Style

González-Domínguez, R.; Sayago, A.; Fernández-Recamales, Á. High-Throughput Direct Mass Spectrometry-Based Metabolomics to Characterize Metabolite Fingerprints Associated with Alzheimer’s Disease Pathogenesis. Metabolites 2018, 8, 52. https://doi.org/10.3390/metabo8030052

AMA Style

González-Domínguez R, Sayago A, Fernández-Recamales Á. High-Throughput Direct Mass Spectrometry-Based Metabolomics to Characterize Metabolite Fingerprints Associated with Alzheimer’s Disease Pathogenesis. Metabolites. 2018; 8(3):52. https://doi.org/10.3390/metabo8030052

Chicago/Turabian Style

González-Domínguez, Raúl, Ana Sayago, and Ángeles Fernández-Recamales. 2018. "High-Throughput Direct Mass Spectrometry-Based Metabolomics to Characterize Metabolite Fingerprints Associated with Alzheimer’s Disease Pathogenesis" Metabolites 8, no. 3: 52. https://doi.org/10.3390/metabo8030052

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