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High-Throughput Direct Mass Spectrometry-Based Metabolomics to Characterize Metabolite Fingerprints Associated with Alzheimer’s Disease Pathogenesis

1
Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain
2
International Campus of Excellence ceiA3, University of Huelva, 21007 Huelva, Spain
3
Biomarkers & Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Metabolites 2018, 8(3), 52; https://doi.org/10.3390/metabo8030052
Received: 23 August 2018 / Revised: 8 September 2018 / Accepted: 14 September 2018 / Published: 18 September 2018
(This article belongs to the Special Issue Metabolomics in Neurodegenerative Disease)
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Abstract

Direct mass spectrometry-based metabolomics has been widely employed in recent years to characterize the metabolic alterations underlying Alzheimer’s disease development and progression. This high-throughput approach presents great potential for fast and simultaneous fingerprinting of a vast number of metabolites, which can be applied to multiple biological matrices including serum/plasma, urine, cerebrospinal fluid and tissues. In this review article, we present the main advantages and drawbacks of metabolomics based on direct mass spectrometry compared with conventional analytical techniques, and provide a comprehensive revision of the literature on the use of these tools in the investigation of Alzheimer’s disease. View Full-Text
Keywords: metabolomics; direct mass spectrometry; Alzheimer’s disease; pathogenesis; biomarkers metabolomics; direct mass spectrometry; Alzheimer’s disease; pathogenesis; biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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González-Domínguez, R.; Sayago, A.; Fernández-Recamales, Á. High-Throughput Direct Mass Spectrometry-Based Metabolomics to Characterize Metabolite Fingerprints Associated with Alzheimer’s Disease Pathogenesis. Metabolites 2018, 8, 52.

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