Next Article in Journal
Carbonic Anhydrases and Metabolism
Previous Article in Journal
GC-MS-Based Endometabolome Analysis Differentiates Prostate Cancer from Normal Prostate Cells
Previous Article in Special Issue
Nanoparticle-Assisted Metabolomics
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessCommunication
Metabolites 2018, 8(1), 24; https://doi.org/10.3390/metabo8010024

Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS

1
Department of Food Science & Technology, The Ohio State University, Columbus, OH 43210, USA
2
The Ohio State Comprehensive Cancer Center, Columbus, OH 43210, USA
3
Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
Current address: The USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
*
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 3 March 2018 / Accepted: 19 March 2018 / Published: 20 March 2018
Full-Text   |   PDF [1630 KB, uploaded 3 May 2018]   |  

Abstract

The carotenoid lycopene is a bioactive component of tomatoes and is hypothesized to reduce risk of several chronic diseases, such as prostate cancer. The metabolism of lycopene is only beginning to be understood and some studies suggest that metabolites of lycopene may be partially responsible for bioactivity associated with the parent compound. The detection and characterization of these compounds in vivo is an important step in understanding lycopene bioactivity. The metabolism of lycopene likely involves both chemical and enzymatic oxidation. While numerous lycopene metabolites have been proposed, few have actually been identified in vivo following lycopene intake. Here, LC-QTOF-MS was used along with 13C-labeling to investigate the post-prandial oxidative metabolism of lycopene in human plasma. Previously reported aldehyde cleavage products were not detected, but a lycopene 1,2-epoxide was identified as a new candidate oxidative metabolite. View Full-Text
Keywords: lycopene; metabolite; mass spectrometry; stable isotopes lycopene; metabolite; mass spectrometry; stable isotopes
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Cichon, M.J.; Moran, N.E.; Riedl, K.M.; Schwartz, S.J.; Clinton, S.K. Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS. Metabolites 2018, 8, 24.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top