Metabolites 2018, 8(1), 10; https://doi.org/10.3390/metabo8010010
Global Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women
Jacquelyn M. Walejko 1, Anushka Chelliah 2, Maureen Keller-Wood 3, Anthony Gregg 4 and Arthur S. Edison 5,*
1
Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL 32610, USA
2
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center at Houston, UT Health, Houston, TX 77030, USA
3
Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610, USA
4
Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610, USA
5
Departments of Genetics and Biochemistry & Molecular Biology, Institute of Bioinformatics, Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
*
Author to whom correspondence should be addressed.
Received: 17 December 2017 / Revised: 16 January 2018 / Accepted: 19 January 2018 / Published: 23 January 2018
(This article belongs to the Special Issue Clinical Metabolomics)
Abstract
We evaluated the metabolic alterations in maternal and fetal placental tissues from non-labored women undergoing cesarean section using samples collected from 5 min to 24 h following delivery. Using 1H-NMR, we identified 14 metabolites that significantly differed between maternal and fetal placental tissues (FDR-corrected p-value < 0.05), with 12 metabolites elevated in the maternal tissue, reflecting the flux of these metabolites from mother to fetus. In the maternal tissue, 4 metabolites were significantly altered at 15 min, 10 metabolites at 30 min, and 16 metabolites at 1 h postdelivery, while 11 metabolites remained stable over 24 h. In contrast, in the fetal placenta tissue, 1 metabolite was significantly altered at 15 min, 2 metabolites at 30 min, and 4 metabolites at 1 h postdelivery, while 22 metabolites remained stable over 24 h. Our study provides information on the metabolic profiles of maternal and fetal placental tissues delivered by cesarean section and reveals that there are different metabolic alterations in the maternal and fetal tissues of the placenta following delivery. View Full-TextKeywords:
pregnancy; human; placenta; metabolomics; 1H-NMR
▼
Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
Walejko, J.M.; Chelliah, A.; Keller-Wood, M.; Gregg, A.; Edison, A.S. Global Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women. Metabolites 2018, 8, 10.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Metabolites
EISSN 2218-1989
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert