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Metabolites
Volume 14
Issue 6
10.3390/metabo14060312
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Review

Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer

by
Ala F. Nassar
1,*,
Xinxin Nie
1,
Tianxiang Zhang
1,
Jacky Yeung
1,
Paul Norris
2,
Jianwei He
1,
Hideki Ogura
3,
Muhammad Usman Babar
4,5,
Anne Muldoon
1,
Stephania Libreros
4,5 and
Lieping Chen
1
1
Department of Immunobiology, Yale University, West Haven, CT 06516, USA
2
Sciex, 500 Old Connecticut Path, Framingham, MA 01701, USA
3
Department of Microbiology, Hyogo Medical University, Nishinomiya 663-8501, Japan
4
Department of Pathology, Yale University, New Haven, CT 06520, USA
5
Vascular Biology and Therapeutic Program, Yale University School of Medicine, New Haven, CT 06520, USA
*
Author to whom correspondence should be addressed.
Metabolites 2024, 14(6), 312; https://doi.org/10.3390/metabo14060312
Submission received: 15 March 2024 / Revised: 12 May 2024 / Accepted: 16 May 2024 / Published: 29 May 2024
(This article belongs to the Special Issue Mass Spectrometry-Based Metabolomics and Lipidomics for Biomarker Discovery and Drug Development)
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Abstract

For either healthy or diseased organisms, lipids are key components for cellular membranes; they play important roles in numerous cellular processes including cell growth, proliferation, differentiation, energy storage and signaling. Exercise and disease development are examples of cellular environment alterations which produce changes in these networks. There are indications that alterations in lipid metabolism contribute to the development and progression of a variety of cancers. Measuring such alterations and understanding the pathways involved is critical to fully understand cellular metabolism. The demands for this information have led to the emergence of lipidomics, which enables the large-scale study of lipids using mass spectrometry (MS) techniques. Mass spectrometry has been widely used in lipidomics and allows us to analyze detailed lipid profiles of cancers. In this article, we discuss emerging strategies for lipidomics by mass spectrometry; targeted, as opposed to global, lipid analysis provides an exciting new alternative method. Additionally, we provide an introduction to lipidomics, lipid categories and their major biological functions, along with lipidomics studies by mass spectrometry in cancer samples. Further, we summarize the importance of lipid metabolism in oncology and tumor microenvironment, some of the challenges for lipodomics, and the potential for targeted approaches for screening pharmaceutical candidates to improve the therapeutic efficacy of treatment in cancer patients.
Keywords: lipids; lipid metabolism; cancer; ion-mobility mass spectrometry (MS); immunity; lipidomics; MS imaging lipids; lipid metabolism; cancer; ion-mobility mass spectrometry (MS); immunity; lipidomics; MS imaging

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MDPI and ACS Style

Nassar, A.F.; Nie, X.; Zhang, T.; Yeung, J.; Norris, P.; He, J.; Ogura, H.; Babar, M.U.; Muldoon, A.; Libreros, S.; et al. Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer. Metabolites 2024, 14, 312. https://doi.org/10.3390/metabo14060312

AMA Style

Nassar AF, Nie X, Zhang T, Yeung J, Norris P, He J, Ogura H, Babar MU, Muldoon A, Libreros S, et al. Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer. Metabolites. 2024; 14(6):312. https://doi.org/10.3390/metabo14060312

Chicago/Turabian Style

Nassar, Ala F., Xinxin Nie, Tianxiang Zhang, Jacky Yeung, Paul Norris, Jianwei He, Hideki Ogura, Muhammad Usman Babar, Anne Muldoon, Stephania Libreros, and et al. 2024. "Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer" Metabolites 14, no. 6: 312. https://doi.org/10.3390/metabo14060312

APA Style

Nassar, A. F., Nie, X., Zhang, T., Yeung, J., Norris, P., He, J., Ogura, H., Babar, M. U., Muldoon, A., Libreros, S., & Chen, L. (2024). Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer. Metabolites, 14(6), 312. https://doi.org/10.3390/metabo14060312

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