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Article

Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice

by
Hsin-Yuan Chen
1,
Yong-Han Hong
2,
Yi-Fen Chiang
1,
Kai-Lee Wang
3,
Tsui-Chin Huang
4,
Mohamed Ali
5,
Tzong-Ming Shieh
6,
Hsin-Yi Chang
7 and
Shih-Min Hsia
1,8,9,10,11,*
1
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
2
Graduate Programs of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 106209, Taiwan
3
Department of Nursing, Ching Kuo Institute of Management and Health, Keelung 20301, Taiwan
4
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
5
Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
6
School of Dentistry, College of Dentistry, China Medical University, Taichung 40402, Taiwan
7
Graduate Institute of Medical Science, National Defense Medical Center, Taipei 114, Taiwan
8
Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
9
School of Food and Safety, Taipei Medical University, Taipei 11031, Taiwan
10
Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan
11
TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 11031, Taiwan
 
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Author to whom correspondence should be addressed.
Metabolites 2022, 12(10), 964; https://doi.org/10.3390/metabo12100964
Submission received: 21 September 2022 / Revised: 8 October 2022 / Accepted: 9 October 2022 / Published: 12 October 2022
(This article belongs to the Special Issue Functional Foods and Diabetes)
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Abstract

Type 2 diabetes mellitus is a complex multifactorial disease characterized by poor glucose tolerance and insulin resistance. Rice-husk silica liquid (RHSL) derived from rice husk has the ability to improve the dysfunction of pancreatic β-cells. This study aimed to confirm the potential protective effects of RHSL in streptozotocin (STZ)-induced diabetic mice. Diabetes was induced in male C57BL/6J mice by intraperitoneal administration of STZ (200 mg/kg BW). RHSL, food-grade silica liquid (FDSL), and rosiglitazone (RSG) were administered to diabetic mice for 12 weeks after successful induction of diabetes. During the experiment, fasting blood glucose, serum insulin, and organ weights were measured. The histopathology of liver tissue was evaluated by H&E staining. Western blotting was performed to assess protein expression levels. The results showed that RHSL significantly reversed the serum insulin levels and improved oral glucose tolerance test (OGTT) results (p < 0.05). In addition, liver sections of STZ-induced diabetic mice after RHSL treatment showed neatly arranged and intact hepatocytes. Furthermore, RHSL was more effective than FDSL in increasing the expression of SIRT1 and decreasing the expression of the PPAR-γ and p-NF-κB proteins. Taken together, this study demonstrated that RHSL ameliorated STZ-induced insulin resistance and liver tissue damage in C57BL/6J mice.
Keywords: rice-husk silica liquid; food-grade silica liquid; rosiglitazone; streptozotocin; diabetic liver injury rice-husk silica liquid; food-grade silica liquid; rosiglitazone; streptozotocin; diabetic liver injury
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MDPI and ACS Style

Chen, H.-Y.; Hong, Y.-H.; Chiang, Y.-F.; Wang, K.-L.; Huang, T.-C.; Ali, M.; Shieh, T.-M.; Chang, H.-Y.; Hsia, S.-M. Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice. Metabolites 2022, 12, 964. https://doi.org/10.3390/metabo12100964

AMA Style

Chen H-Y, Hong Y-H, Chiang Y-F, Wang K-L, Huang T-C, Ali M, Shieh T-M, Chang H-Y, Hsia S-M. Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice. Metabolites. 2022; 12(10):964. https://doi.org/10.3390/metabo12100964

Chicago/Turabian Style

Chen, Hsin-Yuan, Yong-Han Hong, Yi-Fen Chiang, Kai-Lee Wang, Tsui-Chin Huang, Mohamed Ali, Tzong-Ming Shieh, Hsin-Yi Chang, and Shih-Min Hsia. 2022. "Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice" Metabolites 12, no. 10: 964. https://doi.org/10.3390/metabo12100964

APA Style

Chen, H.-Y., Hong, Y.-H., Chiang, Y.-F., Wang, K.-L., Huang, T.-C., Ali, M., Shieh, T.-M., Chang, H.-Y., & Hsia, S.-M. (2022). Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice. Metabolites, 12(10), 964. https://doi.org/10.3390/metabo12100964

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