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Article

Metabolomics Defines Complex Patterns of Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation and Potential Cardiovascular Disease Risk

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Centre for Rheumatology Research, Department of Medicine, University College London, London W1CE 6JF, UK
2
Centre for Adolescent Rheumatology versus Arthritis, Department of Medicine, University College London, London W1CE 6JF, UK
3
Centre for Cardiometabolic and Vascular Science, Department of Medicine, University College London, London W1CE 6JF, UK
*
Authors to whom correspondence should be addressed.
Academic Editors: Tamara K. Nowling and German Perdomo
Metabolites 2022, 12(1), 3; https://doi.org/10.3390/metabo12010003
Received: 9 December 2021 / Revised: 14 December 2021 / Accepted: 17 December 2021 / Published: 21 December 2021
Cardiovascular disease (CVD) is a leading cause of mortality in patients with juvenile-onset systemic lupus erythematosus (JSLE) associated with atherosclerosis. The interplay between dyslipidaemia and inflammation—mechanisms that drive atherosclerosis—were investigated retrospectively in adolescent JSLE patients using lipoprotein-based serum metabolomics in patients with active and inactive disease, compared to healthy controls (HCs). Data was analysed using machine learning, logistic regression, and linear regression. Dyslipidaemia in JSLE patients was characterised by lower levels of small atheroprotective high-density lipoprotein subsets compared to HCs. These changes were exacerbated by active disease and additionally associated with significantly higher atherogenic very-low-density lipoproteins (VLDL) compared to patients with low disease activity. Atherogenic lipoprotein subset expression correlated positively with clinical and serological markers of JSLE disease activity/inflammation and was associated with disturbed liver function, and elevated expression of T-cell and B-cell lipid rafts (cell signalling platforms mediating immune cell activation). Finally, exposing VLDL/LDL from patients with active disease to HC lymphocytes induced a significant increase in lymphocyte lipid raft activation compared to VLDL/LDL from inactive patients. Thus, metabolomic analysis identified complex patterns of atherogenic dyslipidaemia in JSLE patients associated with inflammation. This could inform lipid-targeted therapies in JSLE to improve cardiovascular outcomes. View Full-Text
Keywords: juvenile-onset SLE; metabolomics; lipoproteins; lipid rafts; disease activity; cardiovascular disease; atherosclerosis; T-cells; B-cells juvenile-onset SLE; metabolomics; lipoproteins; lipid rafts; disease activity; cardiovascular disease; atherosclerosis; T-cells; B-cells
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MDPI and ACS Style

Robinson, G.A.; Peng, J.; Pineda-Torra, I.; Ciurtin, C.; Jury, E.C. Metabolomics Defines Complex Patterns of Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation and Potential Cardiovascular Disease Risk. Metabolites 2022, 12, 3. https://doi.org/10.3390/metabo12010003

AMA Style

Robinson GA, Peng J, Pineda-Torra I, Ciurtin C, Jury EC. Metabolomics Defines Complex Patterns of Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation and Potential Cardiovascular Disease Risk. Metabolites. 2022; 12(1):3. https://doi.org/10.3390/metabo12010003

Chicago/Turabian Style

Robinson, George A., Junjie Peng, Ines Pineda-Torra, Coziana Ciurtin, and Elizabeth C. Jury. 2022. "Metabolomics Defines Complex Patterns of Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation and Potential Cardiovascular Disease Risk" Metabolites 12, no. 1: 3. https://doi.org/10.3390/metabo12010003

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