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Open AccessArticle

Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach

1
Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, Korea
2
KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Korea
3
Department of Dermatology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul 05278, Korea
4
College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Peter Meikle
Metabolites 2021, 11(3), 178; https://doi.org/10.3390/metabo11030178
Received: 16 February 2021 / Revised: 12 March 2021 / Accepted: 16 March 2021 / Published: 18 March 2021
Pattern baldness has been associated with the male hormone, dihydrotestosterone. In this study, we tried to determine how the overall metabolic pathways of pattern baldness differ in patients and in normal controls. Our study aimed to identify alterations in hair metabolomic profiles in order to identify possible markers of pattern baldness according to sex. Untargeted metabolomics profiling in pattern baldness patients and control subjects was conducted using ultra-performance liquid chromatography-mass spectrometry. To identify significantly altered metabolic pathways, partial least squares discriminant analysis was performed. Our analysis indicated differences in steroid biosynthesis pathway in both males and females. However, there was a remarkable difference in the androgen metabolic pathway in males, and the estrogen metabolic and arachidonic acid pathways in females. For the first time, we were able to confirm the metabolic pathway in pattern baldness patients using hair samples. Our finding improves understanding of pattern baldness and highlights the need to link pattern baldness and sex-related differences. View Full-Text
Keywords: hair metabolomics; ultra-performance liquid chromatography-mass spectrometry; pattern baldness; female; male hair metabolomics; ultra-performance liquid chromatography-mass spectrometry; pattern baldness; female; male
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MDPI and ACS Style

Lee, Y.R.; Lew, B.L.; Sim, W.Y.; Hong, J.; Chung, B.C. Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach. Metabolites 2021, 11, 178. https://doi.org/10.3390/metabo11030178

AMA Style

Lee YR, Lew BL, Sim WY, Hong J, Chung BC. Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach. Metabolites. 2021; 11(3):178. https://doi.org/10.3390/metabo11030178

Chicago/Turabian Style

Lee, Yu R.; Lew, Bark L.; Sim, Woo Y.; Hong, Jongki; Chung, Bong C. 2021. "Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach" Metabolites 11, no. 3: 178. https://doi.org/10.3390/metabo11030178

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