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Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color

1
Department of Forensic Pharmacology & Toxicology, Zurich Institute of Forensic Medicine, University of Zurich, 8057 Zurich, Switzerland
2
Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, 8006 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Metabolites 2020, 10(10), 381; https://doi.org/10.3390/metabo10100381
Received: 7 September 2020 / Revised: 23 September 2020 / Accepted: 25 September 2020 / Published: 26 September 2020
(This article belongs to the Section Endocrinology and Clinical Metabolic Research)
Untargeted metabolomic studies are used for large-scale analysis of endogenous compounds. Due to exceptional long detection windows of incorporated substances in hair, analysis of hair samples for retrospective monitoring of metabolome changes has recently been introduced. However, information on the general behavior of metabolites in hair samples is scarce, hampering correct data interpretation so far. The presented study aimed to investigate endogenous metabolites depending on hair color and along the hair strand and to propose recommendations for best practice in hair metabolomic studies. A metabolite selection was analyzed using untargeted data acquisition in genuine hair samples from different hair colors and after segmentation in 3 cm segments. Significant differences in metabolites among hair colors and segments were found. In conclusion, consideration of hair color and hair segments is necessary for hair metabolomic studies and, subsequently, recommendations for best practice in hair metabolomic studies were proposed. View Full-Text
Keywords: LC-MS/MS; hair metabolomics; hair analysis; endogenous compounds; segmentation; hair color LC-MS/MS; hair metabolomics; hair analysis; endogenous compounds; segmentation; hair color
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MDPI and ACS Style

Eisenbeiss, L.; Binz, T.M.; Baumgartner, M.R.; Kraemer, T.; Steuer, A.E. Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color. Metabolites 2020, 10, 381. https://doi.org/10.3390/metabo10100381

AMA Style

Eisenbeiss L, Binz TM, Baumgartner MR, Kraemer T, Steuer AE. Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color. Metabolites. 2020; 10(10):381. https://doi.org/10.3390/metabo10100381

Chicago/Turabian Style

Eisenbeiss, Lisa; Binz, Tina M.; Baumgartner, Markus R.; Kraemer, Thomas; Steuer, Andrea E. 2020. "Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color" Metabolites 10, no. 10: 381. https://doi.org/10.3390/metabo10100381

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