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Article

In Vitro and In Silico Antistaphylococcal Activity of Indole Alkaloids Isolated from Tabernaemontana cymosa Jacq (Apocynaceae)

1
Laboratory of Phytochemical and Pharmacological Researches, School of Pharmaceutical Sciences, University of Cartagena, Cartagena 130002, Colombia
2
Research Group in Healthcare Pharmacy and Pharmacology, Faculty of Chemistry and Pharmacy, University of Atlántico, Barranquilla 080003, Colombia
3
Organic Chemistry of Natural Products, University of Antioquia, Medellín 050001, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Helen D. Skaltsa
Sci. Pharm. 2022, 90(2), 38; https://doi.org/10.3390/scipharm90020038
Received: 10 May 2022 / Revised: 6 June 2022 / Accepted: 10 June 2022 / Published: 14 June 2022
(This article belongs to the Special Issue Feature Papers in Scientia Pharmaceutica)
The species of the genus Tabernaemontana have a long tradition of use in different pathologies of infectious origins; the antibacterial, antifungal, and antiviral effects related to the control of the pathologies where the species of this genus are used, have been attributed to the indole monoterpene alkaloids, mainly those of the iboga type. There are more than 1000 alkaloids isolated from different species of Tabernaemontana and other genera of the Apocynaceae family, several of which lack studies related to antibacterial activity. In the present study, four monoterpene indole alkaloids were isolated from the seeds of the species Tabernaemontana cymosa Jacq, namely voacangine (1), voacangine-7-hydroxyindolenine (2), 3-oxovoacangine (3), and rupicoline (4), which were tested in an in vitro antibacterial activity study against the bacteria S. aureus, sensitive and resistant to methicillin, and classified by the World Health Organization as critical for the investigation of new antibiotics. Of the four alkaloids tested, only voacangine was active against S. aureus, with an MIC of 50 µg/mL. In addition, an in silico study was carried out between the four isolated alkaloids and some proteins of this bacterium, finding that voacangine also showed binding to proteins involved in cell wall synthesis, mainly PBP2 and PBP2a. View Full-Text
Keywords: monoterpene indol alkaloids; voacangine; PBP2a; methicillin-resistant S. aureus monoterpene indol alkaloids; voacangine; PBP2a; methicillin-resistant S. aureus
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MDPI and ACS Style

Pájaro-González, Y.; Cabrera-Barraza, J.; Martelo-Ramírez, G.; Oliveros-Díaz, A.F.; Urrego-Álvarez, J.; Quiñones-Fletcher, W.; Díaz-Castillo, F. In Vitro and In Silico Antistaphylococcal Activity of Indole Alkaloids Isolated from Tabernaemontana cymosa Jacq (Apocynaceae). Sci. Pharm. 2022, 90, 38. https://doi.org/10.3390/scipharm90020038

AMA Style

Pájaro-González Y, Cabrera-Barraza J, Martelo-Ramírez G, Oliveros-Díaz AF, Urrego-Álvarez J, Quiñones-Fletcher W, Díaz-Castillo F. In Vitro and In Silico Antistaphylococcal Activity of Indole Alkaloids Isolated from Tabernaemontana cymosa Jacq (Apocynaceae). Scientia Pharmaceutica. 2022; 90(2):38. https://doi.org/10.3390/scipharm90020038

Chicago/Turabian Style

Pájaro-González, Yina, Julián Cabrera-Barraza, Geraldine Martelo-Ramírez, Andrés F. Oliveros-Díaz, Juan Urrego-Álvarez, Wiston Quiñones-Fletcher, and Fredyc Díaz-Castillo. 2022. "In Vitro and In Silico Antistaphylococcal Activity of Indole Alkaloids Isolated from Tabernaemontana cymosa Jacq (Apocynaceae)" Scientia Pharmaceutica 90, no. 2: 38. https://doi.org/10.3390/scipharm90020038

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