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Open AccessArticle

Anionic Polyelectrolyte Hydrogel as an Adjuvant for Vaccine Development

1
Institute of Animal Biology of the National Academy of Agrarian Sciences (NAAS) of Ukraine, 79034 Lviv, Ukraine
2
Department of Organic Chemistry, Lviv Polytechnic National University, 79013 Lviv, Ukraine
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2020, 88(4), 56; https://doi.org/10.3390/scipharm88040056
Received: 29 September 2020 / Revised: 22 October 2020 / Accepted: 5 November 2020 / Published: 26 November 2020
Vaccination is one of the main methods for the specific prevention of infectious diseases. The disadvantage of vaccination is the use of pathogens (live or attenuated viruses and bacteria) that can lead to the development of a disease. Recombinant technologies are capable of producing specific DNA or protein molecules that possess antigenic properties and do not cause disease. However, individual antigen molecules are low-immunogenic, and therefore, require conjugation with a compound possessing stronger immunogenic properties. In this study, we examined the immunogenic properties of the new anionic copolymer consisting of glycidyl methacrylate, butyl acrylate, triethylene glycol dimethacrylate, and acrylic acid, in mice. The experimental polymer induced a stronger immunogenic response than aluminum hydroxide. The histological studies have established that immunization both with aluminum hydroxide and the polymer studied does not cause damage to the liver, kidneys, or the spleen. No negative side effects were observed. It has been concluded that the new synthetic anionic polyelectrolyte hydrogel (PHG) has a potential as an adjuvant for vaccine development. View Full-Text
Keywords: adjuvant; anionic polyelectrolyte hydrogel; aluminum hydroxide; vaccine adjuvant; anionic polyelectrolyte hydrogel; aluminum hydroxide; vaccine
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MDPI and ACS Style

Kozak, M.; Mitina, N.; Zaichenko, A.; Vlizlo, V. Anionic Polyelectrolyte Hydrogel as an Adjuvant for Vaccine Development. Sci. Pharm. 2020, 88, 56.

AMA Style

Kozak M, Mitina N, Zaichenko A, Vlizlo V. Anionic Polyelectrolyte Hydrogel as an Adjuvant for Vaccine Development. Scientia Pharmaceutica. 2020; 88(4):56.

Chicago/Turabian Style

Kozak, Mariya; Mitina, Nataliya; Zaichenko, Alexandr; Vlizlo, Vasyl. 2020. "Anionic Polyelectrolyte Hydrogel as an Adjuvant for Vaccine Development" Sci. Pharm. 88, no. 4: 56.

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