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Open AccessReview

Antiviral Activity of Ivermectin Against SARS-CoV-2: An Old-Fashioned Dog with a New Trick—A Literature Review

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Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh 2311, Indonesia
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Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh 23111, Indonesia
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Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh 23111, Indonesia
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Department of Family Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh 23111, Indonesia
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Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia
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Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari 55861, Indonesia
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Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tübingen, 72076 Tübingen, Germany
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Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Warmadewa University, Denpasar 80239, Indonesia
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Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, CA 95616, USA
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Department of Parasitology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh 23111, Indonesia
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Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India
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Authors to whom correspondence should be addressed.
Sci. Pharm. 2020, 88(3), 36; https://doi.org/10.3390/scipharm88030036
Received: 20 July 2020 / Revised: 31 July 2020 / Accepted: 10 August 2020 / Published: 17 August 2020
The coronavirus disease 2019 (COVID-19) pandemic is a major global threat. With no effective antiviral drugs, the repurposing of many currently available drugs has been considered. One such drug is ivermectin, an FDA-approved antiparasitic agent that has been shown to exhibit antiviral activity against a broad range of viruses. Recent studies have suggested that ivermectin inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus suggesting its potential for use against COVID-19. This review has summarized the evidence derived from docking and modeling analysis, in vitro and in vivo studies, and results from new investigational drug protocols, as well as clinical trials, if available, which will be effective in supporting the prospective use of ivermectin as an alternative treatment for COVID-19. View Full-Text
Keywords: SARS-CoV-2; COVID-19; ivermectin; treatment; antiviral SARS-CoV-2; COVID-19; ivermectin; treatment; antiviral
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MDPI and ACS Style

Mudatsir, M.; Yufika, A.; Nainu, F.; Frediansyah, A.; Megawati, D.; Pranata, A.; Mahdani, W.; Ichsan, I.; Dhama, K.; Harapan, H. Antiviral Activity of Ivermectin Against SARS-CoV-2: An Old-Fashioned Dog with a New Trick—A Literature Review. Sci. Pharm. 2020, 88, 36.

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