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Open AccessArticle

Water-Soluble Fiber from Bengkoang (Pachyrhizus erosus (L.) Urban) Tuber Modulates Immune System Activity in Male Mice

1
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Yogyakarta 55281, Indonesia
2
Department of Pharmacy, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto 53122, Indonesia
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Yogyakarta 55281, Indonesia
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2020, 88(3), 34; https://doi.org/10.3390/scipharm88030034
Received: 12 July 2020 / Revised: 27 July 2020 / Accepted: 30 July 2020 / Published: 10 August 2020
Our previous study showed that water-soluble fiber from bengkoang (Pachyrizus erosus (L.) Urban) fiber extract (BFE) and bengkoang fiber fraction B (BFE-B) have phagocytic activity and modulation of cytokine production in vitro. The present study evaluates the immunomodulatory effects of water-soluble fibers BFE and BFE-B on male mice induced by hepatitis B vaccine. Thirty mice were divided into six groups and induced by hepatitis B vaccine intraperitoneally on days 7 and 14. The mice were then treated with BFE, BFE-B, levamisole, or sodium carboxymethyl cellulose for 18 days. At the end of the treatments (day 19), phagocytic activity, lymphocyte proliferation, spleen index, cytokine, and immunoglobulin G (IgG) production were determined. The results showed that the water-soluble fiber treatment could significantly increase phagocytic capacity, nitric oxide production, and spleen index. However, BFE-B could modulate tumor necrosis factor (TNF)-α and interleukin (IL)-10 secretion, BFE demonstrated no such effect on cytokine production. Lymphocyte proliferation assay revealed that treatment with 50 mg/kg body weight (BW) BFE and 50 mg/kg BW BFE-B could significantly enhance lymphocyte proliferation. Treatment with 25 and 50 mg/kg BW BFE-B stimulated IgG production. In conclusion, BFE and BFE-B similarly have immunomodulatory effects on innate immune responses. BFE-B further demonstrated immunomodulatory effects on adaptive immune responses. View Full-Text
Keywords: immunomodulatory effect; Pachyrhizus erosus (L.) urban; water-soluble fiber; phagocytic activity; adaptive immune immunomodulatory effect; Pachyrhizus erosus (L.) urban; water-soluble fiber; phagocytic activity; adaptive immune
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Baroroh, H.N.; Nugroho, A.E.; Lukitaningsih, E.; Nurrochmad, A. Water-Soluble Fiber from Bengkoang (Pachyrhizus erosus (L.) Urban) Tuber Modulates Immune System Activity in Male Mice. Sci. Pharm. 2020, 88, 34.

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