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Vascular Occlusion Restores Endothelium-Dependent Effects of Adenosine Previously Diminished by Diabetes: The Preliminary Report

1
Department of Pharmacology, Clinical Pharmacology, and Toxicology, Faculty of Medicine, University of Belgrade, 11000 Beograd, Serbia
2
Institute of Pathology, Faculty of Medicine, University of Belgrade, 11000 Beograd, Serbia
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2018, 86(4), 51; https://doi.org/10.3390/scipharm86040051
Received: 23 October 2018 / Revised: 25 November 2018 / Accepted: 30 November 2018 / Published: 4 December 2018
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Abstract

The aim of this study was to investigate the effect of adenosine in non-occluded or occluded femoral arteries (FA) that were isolated from healthy or diabetic Wistar rats. Determining the role of endothelium, and a transmembrane flow of potassium ions in adenosine actions were also of interest. Diabetes was experimentally induced by alloxan, while the vascular occlusion was performed for 45 min on randomly selected FA. Vascular tone changes were continuously recorded. Selected markers of endothelial dysfunction were measured in animal serum. Thus, adenosine produced a concentration-dependent relaxation of rat FA, which was endothelium-dependent, too, except in a group of diabetic animals. Moreover, serum asymmetric dimethylarginine (ADMA) levels were higher in diabetic animals, thus reflecting endothelial dysfunction (ED). Still, an occlusion of FA enhanced the relaxation effect of adenosine in endothelium-intact rings from diabetic animals. Oppositely, in the presence of high potassium concentration in the buffer, adenosine-induced relaxation was significantly reduced in all of the investigated groups/subgroups. These results suggest that in diabetic animals, an occlusion of FA most probably reversed adenosine-induced relaxation from endothelium-independent into an endothelium-dependent relaxation, thus indicating the possible protective mechanism against ischemic episodes of FA in the presence of diabetes. View Full-Text
Keywords: adenosine; diabetes; vascular occlusion; endothelial dysfunction; potassium adenosine; diabetes; vascular occlusion; endothelial dysfunction; potassium
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Stojanović, M.; Janković, R.; Prostran, M.; Radenković, M. Vascular Occlusion Restores Endothelium-Dependent Effects of Adenosine Previously Diminished by Diabetes: The Preliminary Report. Sci. Pharm. 2018, 86, 51.

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