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NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells

1
Institute of Problems of Chemical Physics RAS, 142432 Chernogolovka, Russia
2
Faculty of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia
3
Medicinal Chemistry Research and Education Center, Moscow Region State University, 141014 Mytishchi, Russia
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2018, 86(4), 46; https://doi.org/10.3390/scipharm86040046
Received: 5 September 2018 / Revised: 8 October 2018 / Accepted: 9 October 2018 / Published: 11 October 2018
NO donating iron nitrosyl complex with 2-aminothiophenyl ligand (2-AmPh complex) was studied for its ability to cause cell death and affect nuclear factor kappa B (NF-κB) signaling. The complex inhibited viability of HeLa cells and induced cell death that was accompanied by loss of mitochondrial membrane potential and characteristic for apoptosis phosphatidylserine externalization. At IC50, 2-AmPh caused decrease in nuclear content of NF-κB p65 polypeptide and mRNA expression of NF-κB target genes encoding interleukin-8 and anti-apoptotic protein BIRC3. mRNA levels of interleukin-6 and anti-apoptotic protein BIRC2 encoding genes were not affected. Our data demonstrate that NO donating iron nitrosyl complex 2-AmPh can inhibit tumor cell viability and induce apoptosis that is preceded by impairment of NF-κB function and suppression of a subset of NF-κB target genes. View Full-Text
Keywords: iron nitrosyl complex; 2-aminothiophenyl; apoptosis; NF-κB; p65; IL6; IL8; BIRC2; BIRC3 iron nitrosyl complex; 2-aminothiophenyl; apoptosis; NF-κB; p65; IL6; IL8; BIRC2; BIRC3
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MDPI and ACS Style

Stupina, T.; Balakina, A.; Kondrat’eva, T.; Kozub, G.; Sanina, N.; Terent’ev, A. NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells. Sci. Pharm. 2018, 86, 46.

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