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The Structure and Activity of Double-Nitroimidazoles. A Mini-Review

Pharmaceutical Faculty, Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland
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Sci. Pharm. 2018, 86(3), 30; https://doi.org/10.3390/scipharm86030030
Received: 10 June 2018 / Revised: 14 July 2018 / Accepted: 16 July 2018 / Published: 25 July 2018
Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this article is to overview the literature concerning active compounds that contain two nitroimidazole moieties in their structures. View Full-Text
Keywords: nitroimidazoles; double-nitroimidazoles; bis-nitroimidazoles; tumor hypoxia; radiosensitizers nitroimidazoles; double-nitroimidazoles; bis-nitroimidazoles; tumor hypoxia; radiosensitizers
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Żwawiak, J.; Zaprutko, L. The Structure and Activity of Double-Nitroimidazoles. A Mini-Review. Sci. Pharm. 2018, 86, 30.

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