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Sci. Pharm. 2016, 84(3), 447-455;

A Facile, Improved Synthesis of Sildenafil and Its Analogues

Aurobindo Pharma Limited Research Centre-II, Survey No. 71&72, Indrakaran Village, Sangareddy Mandal, Medak District 502329, Telangana, India
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500085, Telangana, India
Author to whom correspondence should be addressed.
Academic Editor: Thomas Erker
Received: 17 July 2015 / Accepted: 18 October 2015 / Published: 18 October 2015
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This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with infrared (IR), 1H-NMR and 13C-NMR spectroscopic methods, and high resolution mass spectroscopy (HRMS) analysis. View Full-Text
Keywords: sildenafil; chlorosulfonation; novel analogues sildenafil; chlorosulfonation; novel analogues

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Raghava Reddy, A.V.; Srinivas, G.; Takshinamoorthy, C.; Gupta Peruri, B.; Naidu, A. A Facile, Improved Synthesis of Sildenafil and Its Analogues. Sci. Pharm. 2016, 84, 447-455.

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