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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2015, 83(3), 413-427;

Improved Automated Radiosynthesis of [11C]PBR28

Department of Radiology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Author to whom correspondence should be addressed.
Received: 7 May 2015 / Accepted: 19 June 2015 / Published: 19 June 2015
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Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [11C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates. In this study, we optimized the radiolabeling procedure of [11C]PBR28 for higher radiochemical yield, radiochemical purity, and specific activity, which can be easily translated to any automated module for clinical trials. Time-activity curves (TACs) derived from the dynamic PET imaging of male rhesus monkey brains demonstrated that [11C]PBR28 had suitable kinetics with radiotracer accumulation observed in the caudate, putamen, cerebellum, and frontal cortex region.
Keywords: Positron Emission Tomography (PET); Microglial activation; Synthesis; TSPO Positron Emission Tomography (PET); Microglial activation; Synthesis; TSPO
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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SOLINGAPURAM SAI, K.K.; GAGE, D.; NADER, M.; MACH, R.H.; MINTZ, A. Improved Automated Radiosynthesis of [11C]PBR28. Sci. Pharm. 2015, 83, 413-427.

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