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Article

Role of an Ethanolic Extract of Crotalaria juncea L. on High-Fat Diet-Induced Hypercholesterolemia

by
Dinakaran SATHIS KUMAR
1,2,*,
Banji DAVID
3,
Avasarala HARANI
1 and
Bhaskar VIJAY
4
1
Aditya Institute of Pharmaceutical Sciences and Research, Surampalem, Andhra Pradesh, 533437, India
2
Jawaharlal Nehru Technical University, Hyderabad, Andhra Pradesh, India
3
Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, 508001, India
4
Rangaraya Medical College, Kakinada, Andhra Pradesh, 533003, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2014, 82(2), 393-410; https://doi.org/10.3797/scipharm.1308-08
Submission received: 12 August 2013 / Accepted: 20 February 2014 / Published: 20 February 2014

Abstract

Objective: To evaluate the antihypercholesterolemic effects of 50 mg/kg BW and 100 mg/kg BW per day of an ethanolic extract of Crotalaria juncea Linn (whole plant) by performing in vivo studies. Methods: The effects of oral administration of 50 mg/kg BW and 100 mg/kg BW per day of an ethanolic extract of Crotalaria juncea Linn (whole plant) in rats fed with a high-fat diet were investigated by evaluating parameters like food consumption, weight gain, fecal fat excretion, serum and liver lipids, and biochemical profiles as well as by histopathological studies. The results were compared to animals fed with the standard diet and animals fed with a high-fat diet and atorvastatin (10 mg/kg BW). Results: The animal group administered with the ethanolic extract for 35 days showed decreased levels of TC, LDL, VLDL, TG, HDL+VLDL, VLDL+LDL, LDL/TC, AI, SGOT, SGPT, and elevated levels of HDL, HDL/TC, significantly (p<0.01 & p<0.05) in a dose-dependent manner. The evaluation of liver tissues of the animal groups treated with the herbal extract and standard had shown increased levels of SOD, GSH, and catalase, whereas levels of SGOT, SGPT, total glucose, HMG-CoA, lipase, amylase, and the percentage of malon-dialdehyde were decreased when compared with the high-fat diet-fed rats. Body weight and food intake in the treated groups were significantly lower than that in the model control.Objective: To evaluate the antihypercholesterolemic effects of 50 mg/kg BW and 100 mg/kg BW per day of an ethanolic extract of Crotalaria juncea Linn (whole plant) by performing in vivo studies. Methods: The effects of oral administration of 50 mg/kg BW and 100 mg/kg BW per day of an ethanolic extract of Crotalaria juncea Linn (whole plant) in rats fed with a high-fat diet were investigated by evaluating parameters like food consumption, weight gain, fecal fat excretion, serum and liver lipids, and biochemical profiles as well as by histopathological studies. The results were compared to animals fed with the standard diet and animals fed with a high-fat diet and atorvastatin (10 mg/kg BW). Results: The animal group administered with the ethanolic extract for 35 days showed decreased levels of TC, LDL, VLDL, TG, HDL+VLDL, VLDL+LDL, LDL/TC, AI, SGOT, SGPT, and elevated levels of HDL, HDL/TC, significantly (p<0.01 & p<0.05) in a dose-dependent manner. The evaluation of liver tissues of the animal groups treated with the herbal extract and standard had shown increased levels of SOD, GSH, and catalase, whereas levels of SGOT, SGPT, total glucose, HMG-CoA, lipase, amylase, and the percentage of malon-dialdehyde were decreased when compared with the high-fat diet-fed rats. Body weight and food intake in the treated groups were significantly lower than that in the model control. Conclusion: The present study showed that an ethanolic extract of Crotalaria juncea L. influences several blood lipid and metabolic parameters in rats, suggesting a potential benefit as an antihypercholesterolemic agent.Conclusion: The present study showed that an ethanolic extract of Crotalaria juncea L. influences several blood lipid and metabolic parameters in rats, suggesting a potential benefit as an antihypercholesterolemic agent.
Keywords: Crotalaria juncea L.; High-fat diet; Lipid profile; Histopathological studies Crotalaria juncea L.; High-fat diet; Lipid profile; Histopathological studies

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MDPI and ACS Style

SATHIS KUMAR, D.; DAVID, B.; HARANI, A.; VIJAY, B. Role of an Ethanolic Extract of Crotalaria juncea L. on High-Fat Diet-Induced Hypercholesterolemia. Sci. Pharm. 2014, 82, 393-410. https://doi.org/10.3797/scipharm.1308-08

AMA Style

SATHIS KUMAR D, DAVID B, HARANI A, VIJAY B. Role of an Ethanolic Extract of Crotalaria juncea L. on High-Fat Diet-Induced Hypercholesterolemia. Scientia Pharmaceutica. 2014; 82(2):393-410. https://doi.org/10.3797/scipharm.1308-08

Chicago/Turabian Style

SATHIS KUMAR, Dinakaran, Banji DAVID, Avasarala HARANI, and Bhaskar VIJAY. 2014. "Role of an Ethanolic Extract of Crotalaria juncea L. on High-Fat Diet-Induced Hypercholesterolemia" Scientia Pharmaceutica 82, no. 2: 393-410. https://doi.org/10.3797/scipharm.1308-08

APA Style

SATHIS KUMAR, D., DAVID, B., HARANI, A., & VIJAY, B. (2014). Role of an Ethanolic Extract of Crotalaria juncea L. on High-Fat Diet-Induced Hypercholesterolemia. Scientia Pharmaceutica, 82(2), 393-410. https://doi.org/10.3797/scipharm.1308-08

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