Cytotoxic Compounds from Brucea mollis
AbstractTen compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), α-tocopherol (8), inosine (9), and apigenin 7-O-β-D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one- and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth), LU-1 (human lung adenocarcinoma), LNCaP (human prostate adeno-carcinoma), and HL-60 (human promyelocytic leukemia) cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 μg/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1–4 μg/mL. Compounds 9-methoxycanthin-6-one (3) and niloticine (5) have been discovered for the first time from the Brucea genus.
Share & Cite This Article
TUNG, M.H.T.; ĐUC, H.V.; HUONG, T.T.; DUONG, N.T.; PHUONG, D.T.; THAO, D.T.; TAI, B.H.; KIM, Y.H.; BACH, T.T.; CUONG, N.M. Cytotoxic Compounds from Brucea mollis. Sci. Pharm. 2013, 81, 819-832.
TUNG MHT, ĐUC HV, HUONG TT, DUONG NT, PHUONG DT, THAO DT, TAI BH, KIM YH, BACH TT, CUONG NM. Cytotoxic Compounds from Brucea mollis. Scientia Pharmaceutica. 2013; 81(3):819-832.Chicago/Turabian Style
TUNG, Mai H.T.; ĐUC, Ho V.; HUONG, Tran T.; DUONG, Nguyen T.; PHUONG, Do T.; THAO, Do T.; TAI, Bui H.; KIM, Young H.; BACH, Tran T.; CUONG, Nguyen M. 2013. "Cytotoxic Compounds from Brucea mollis." Sci. Pharm. 81, no. 3: 819-832.