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Volume 81
Issue 2
10.3797/scipharm.1302-08
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Review

An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases

by
FARIDOON
1,* and
Nazar UL ISLAM
2
1
Chemistry Department, Islamia College University, Peshawar-25120, Pakistan
2
Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(2), 309-328; https://doi.org/10.3797/scipharm.1302-08
Submission received: 18 February 2013 / Accepted: 28 March 2013 / Published: 28 March 2013
Versions Notes

Abstract

The production of metallo-β-lactamases is the most important strategy by which pathogenic bacteria become resistant to currently known β-lactam antibiotics. The emergence of these enzymes is particularly concerning for the future treatment of bacterial infections. There are no clinically available drugs capable of inhibiting any of the metallo-β-lactamases, so there is an urgent need to find such inhibitors. In this review, an up-to-date status of the inhibitors investigated for the inhibition of metallo-β-lactamases has been given so that this rich source of structural information of presently known metallo-β-lactamases could be helpful in generating a broad-spectrum potent inhibitor of metallo-β-lactamases.
Keywords: Metallo-beta-lactamases; Inhibition; Thiol; β-Lactam analogues; Peptides; Biphenyl tetrazoles; Triazoles Metallo-beta-lactamases; Inhibition; Thiol; β-Lactam analogues; Peptides; Biphenyl tetrazoles; Triazoles

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MDPI and ACS Style

FARIDOON; ISLAM, N.U. An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases. Sci. Pharm. 2013, 81, 309-328. https://doi.org/10.3797/scipharm.1302-08

AMA Style

FARIDOON, ISLAM NU. An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases. Scientia Pharmaceutica. 2013; 81(2):309-328. https://doi.org/10.3797/scipharm.1302-08

Chicago/Turabian Style

FARIDOON, and Nazar UL ISLAM. 2013. "An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases" Scientia Pharmaceutica 81, no. 2: 309-328. https://doi.org/10.3797/scipharm.1302-08

APA Style

FARIDOON, & ISLAM, N. U. (2013). An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases. Scientia Pharmaceutica, 81(2), 309-328. https://doi.org/10.3797/scipharm.1302-08

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