Identification of Major Degradation Products of Ketoconazole
1
Sharon Bio Medicine, 312, C-Wing, BSEL Tech Park, Opp. Vashi Railway Station, Sector 30 (A), Vashi, Navi-Mumbai-400703, India
2
Shri Jagdishprasad Jhabarmal Tiberewala University, J. B. Nagar, Andheri (E), Mumbai–400059, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(4), 817-836; https://doi.org/10.3797/scipharm.1107-18
Submission received: 14 July 2011
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Accepted: 13 October 2011
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Published: 13 October 2011
Abstract
Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS-3V, length 100 X diameter 4.6 mm, particle size 3 μm column using gradient method. These degradants were identified by LC-MS technique.
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MDPI and ACS Style
MHASKE, R.A.; SAHASRABUDHE, S. Identification of Major Degradation Products of Ketoconazole. Sci. Pharm. 2011, 79, 817-836. https://doi.org/10.3797/scipharm.1107-18
AMA Style
MHASKE RA, SAHASRABUDHE S. Identification of Major Degradation Products of Ketoconazole. Scientia Pharmaceutica. 2011; 79(4):817-836. https://doi.org/10.3797/scipharm.1107-18
Chicago/Turabian StyleMHASKE, Rajendra A., and Shirish SAHASRABUDHE. 2011. "Identification of Major Degradation Products of Ketoconazole" Scientia Pharmaceutica 79, no. 4: 817-836. https://doi.org/10.3797/scipharm.1107-18
