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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2011, 79(4), 817-836;

Identification of Major Degradation Products of Ketoconazole

Sharon Bio Medicine, 312, C-Wing, BSEL Tech Park, Opp. Vashi Railway Station, Sector 30 (A), Vashi, Navi-Mumbai-400703, India
Shri Jagdishprasad Jhabarmal Tiberewala University, J. B. Nagar, Andheri (E), Mumbai–400059, India
Author to whom correspondence should be addressed.
Received: 14 July 2011 / Accepted: 13 October 2011 / Published: 13 October 2011
PDF [703 KB, uploaded 28 September 2016]


Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS-3V, length 100 X diameter 4.6 mm, particle size 3 μm column using gradient method. These degradants were identified by LC-MS technique.
Keywords: Ketoconazole; Stress degradation; Hydrolysis degradent; Oxidative degradent; LC-MS Ketoconazole; Stress degradation; Hydrolysis degradent; Oxidative degradent; LC-MS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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MHASKE, R.A.; SAHASRABUDHE, S. Identification of Major Degradation Products of Ketoconazole. Sci. Pharm. 2011, 79, 817-836.

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