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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2010, 78(3), 727-728; https://doi.org/10.3797/scipharm.cespt.8.POT12 (registering DOI)

Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter

1
School of Engineering, Warwick University, Coventry, United Kingdom
2
AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom
*
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
PDF [129 KB, uploaded 11 October 2016]

Abstract

A mathematical model has been developed describing the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor of the BCRP, Fumitremorgin C (FTC), present. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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GRANDJEAN, T.R.B.; YATES, J.T.W.; CHAPPELL, M.J. Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter. Sci. Pharm. 2010, 78, 727-728.

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