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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(Posters (PO)), 202; (registering DOI)

Ligand Based Screening Tools for Insulin Receptor Activating Compounds

Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Current treatments of type 2 diabetes mellitus have sometimes severe side effects. Therefore, the identification of new treatments is still an urgent need. The binding of insulin to the extracellular part of the insulin receptor is a key step in the insulin signalling pathway. As type 2 diabetes is characterized among others by a resistance of cells against insulin, activating the insulin receptor might be an interesting approach. In 1999, Zhang et al. discovered a small molecule from a fungal extract which activates the human insulin receptor by binding directly to its intracellular domain [1]. This compound (L-783,281 or demethylasterriquinone B-1, DMAQ-B1) was shown to lower blood glucose levels in mouse models of type 2 diabetes mellitus.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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DIGLES, D.; DIRSCH, V.M.; ECKER, G.F. Ligand Based Screening Tools for Insulin Receptor Activating Compounds. Sci. Pharm. 2009, 77, 202.

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