Next Article in Journal
Induced Fit Docking into a SERT Homology Model
Previous Article in Journal
QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessAbstract
Sci. Pharm. 2009, 77(Posters (PO)), 202; https://doi.org/10.3797/scipharm.oephg.21.PO-03 (registering DOI)

Ligand Based Screening Tools for Insulin Receptor Activating Compounds

1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
2
Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
PDF [201 KB, uploaded 12 May 2017]

Abstract

Current treatments of type 2 diabetes mellitus have sometimes severe side effects. Therefore, the identification of new treatments is still an urgent need. The binding of insulin to the extracellular part of the insulin receptor is a key step in the insulin signalling pathway. As type 2 diabetes is characterized among others by a resistance of cells against insulin, activating the insulin receptor might be an interesting approach. In 1999, Zhang et al. discovered a small molecule from a fungal extract which activates the human insulin receptor by binding directly to its intracellular domain [1]. This compound (L-783,281 or demethylasterriquinone B-1, DMAQ-B1) was shown to lower blood glucose levels in mouse models of type 2 diabetes mellitus.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

DIGLES, D.; DIRSCH, V.M.; ECKER, G.F. Ligand Based Screening Tools for Insulin Receptor Activating Compounds. Sci. Pharm. 2009, 77, 202.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top