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Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B
by
R. R. BAUMGARTNER 1,*, T. M. STEINDL 3, D. SCHUSTER 3, J. M. ROLLINGER 2, G. WOLBER 3, H. STUPPNER 2, A. G. ATANASOV 1, E. H. HEISS 1 and V. M. DIRSCH 1
R. R. BAUMGARTNER 1,*, T. M. STEINDL 3, D. SCHUSTER 3, J. M. ROLLINGER 2, G. WOLBER 3, H. STUPPNER 2, A. G. ATANASOV 1, E. H. HEISS 1 and V. M. DIRSCH 1
1
Department of Pharmacognosy, University of Vienna, Althanstr. 14, 1090, Vienna, Austria
2
Department of Pharmacognosy, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria
3
Department of Pharmaceutical Chemistry, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(Short Lectures (SL)), 199; https://doi.org/10.3797/scipharm.oephg.21.SL-32
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
The protein tyrosine phosphatase 1B (PTP1B) is an important negative regulator of the insulin receptor. Elchebly M. et al showed that PTP1B knockout mice enhanced insulin sensitivity and were completely healthy and resistant to weight gain when put on a high fat diet (1). This makes PTP1B a promising target for diabetes type 2 and metabolic syndrome.
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MDPI and ACS Style
BAUMGARTNER, R.R.; STEINDL, T.M.; SCHUSTER, D.; ROLLINGER, J.M.; WOLBER, G.; STUPPNER, H.; ATANASOV, A.G.; HEISS, E.H.; DIRSCH, V.M. Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B. Sci. Pharm. 2009, 77, 199.
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