Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B

R. R. BAUMGARTNER; T. M. STEINDL; D. SCHUSTER; J. M. ROLLINGER; G. WOLBER; H. STUPPNER; A. G. ATANASOV; E. H. HEISS; V. M. DIRSCH

doi:10.3797/scipharm.oephg.21.SL-32

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Abstract

16 April 2009

Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B

and

Department of Pharmacognosy, University of Vienna, Althanstr. 14, 1090, Vienna, Austria

Department of Pharmacognosy, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria

Department of Pharmaceutical Chemistry, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria

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Sci. Pharm.2009, 77(6), 199;https://doi.org/10.3797/scipharm.oephg.21.SL-32

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Abstract

The protein tyrosine phosphatase 1B (PTP1B) is an important negative regulator of the insulin receptor. Elchebly M. et al showed that PTP1B knockout mice enhanced insulin sensitivity and were completely healthy and resistant to weight gain when put on a high fat diet (1). This makes PTP1B a promising target for diabetes type 2 and metabolic syndrome.

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