Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016).
Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence.
Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Sci. Pharm. 2009, 77(Short Lectures (SL)), 199; https://doi.org/10.3797/scipharm.oephg.21.SL-32 (registering DOI)
Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B
1
Department of Pharmacognosy, University of Vienna, Althanstr. 14, 1090, Vienna, Austria
2
Department of Pharmacognosy, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria
3
Department of Pharmaceutical Chemistry, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
PDF [220 KB, uploaded 12 May 2017]
Abstract
The protein tyrosine phosphatase 1B (PTP1B) is an important negative regulator of the insulin receptor. Elchebly M. et al showed that PTP1B knockout mice enhanced insulin sensitivity and were completely healthy and resistant to weight gain when put on a high fat diet (1). This makes PTP1B a promising target for diabetes type 2 and metabolic syndrome.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
BAUMGARTNER, R.R.; STEINDL, T.M.; SCHUSTER, D.; ROLLINGER, J.M.; WOLBER, G.; STUPPNER, H.; ATANASOV, A.G.; HEISS, E.H.; DIRSCH, V.M. Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B. Sci. Pharm. 2009, 77, 199.
Article Metrics
Comments
[Return to top]
Sci. Pharm.
EISSN 2218-0532
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert