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Sci. Pharm.
Volume 77
Issue 6
10.3797/scipharm.oephg.21.SL-02
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

HPLC-ESI-MS/MS Assay for Quantitative Metabolic Profiling in Fermentation Broths from β–Lactam Antibiotics Production

by
M. LÄMMERHOFER
*,
S. SCHIESEL
,
B. PREINERSTORFER
and
W. LINDNER
Christian-Doppler Laboratory for Molecular Recognition Materials, Department of Analytical Chemistry and Food Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(6), 169; https://doi.org/10.3797/scipharm.oephg.21.SL-02
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

Recent efforts for the optimization of biotechnological production processes such as for β-lactam antibiotics comprise, amongst others, metabolomics-based methodologies. In metabolic profiling approaches it is aimed at measuring quantitatively time-dependent concentration profiles of intra- and extracellular metabolites, nutrients, target product compounds and their intermediates. It is the goal to monitor concentration variations of as many substances as possible in the course of fermentation processes with adequate sampling at regular reasonably short time intervals, allowing to draw conclusions on the progression of the fermentation. Information gained from such analytical measurements should ultimately lead to better understanding of the production process and improvements in the productivity.

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MDPI and ACS Style

LÄMMERHOFER, M.; SCHIESEL, S.; PREINERSTORFER, B.; LINDNER, W. HPLC-ESI-MS/MS Assay for Quantitative Metabolic Profiling in Fermentation Broths from β–Lactam Antibiotics Production. Sci. Pharm. 2009, 77, 169. https://doi.org/10.3797/scipharm.oephg.21.SL-02

AMA Style

LÄMMERHOFER M, SCHIESEL S, PREINERSTORFER B, LINDNER W. HPLC-ESI-MS/MS Assay for Quantitative Metabolic Profiling in Fermentation Broths from β–Lactam Antibiotics Production. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):169. https://doi.org/10.3797/scipharm.oephg.21.SL-02

Chicago/Turabian Style

LÄMMERHOFER, M., S. SCHIESEL, B. PREINERSTORFER, and W. LINDNER. 2009. "HPLC-ESI-MS/MS Assay for Quantitative Metabolic Profiling in Fermentation Broths from β–Lactam Antibiotics Production" Scientia Pharmaceutica 77, Short Lectures (SL): 169. https://doi.org/10.3797/scipharm.oephg.21.SL-02

APA Style

LÄMMERHOFER, M., SCHIESEL, S., PREINERSTORFER, B., & LINDNER, W. (2009). HPLC-ESI-MS/MS Assay for Quantitative Metabolic Profiling in Fermentation Broths from β–Lactam Antibiotics Production. Scientia Pharmaceutica, 77(Short Lectures (SL)), 169. https://doi.org/10.3797/scipharm.oephg.21.SL-02

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