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Article

The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative

1
Wroclaw University of Medicine, Faculty of Pharmacy, Department of Organic Chemistry, ul. Grodzka 9, 50-1 37 Wroclaw, Poland
2
Institute of Genetic and Microbiology Wroclaw University, ul. Przybyszewskiego 63/72, 51-148 Wrocław, Poland
3
lnstitut Curie Recherche, Bâtiment 112, Centre Universitaire - 91405 Orsay cedex, France
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2005, 73(3), 101-112; https://doi.org/10.3797/scipharm.aut-05-09
Received: 29 October 2004 / Accepted: 20 March 2005 / Published: 30 September 2005
Starting from 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine and 2-methylisonicotinic acid, 9-hydroxy-5,6-dimethyl-1-(2-methylpyridin-4-yl)-6H-pyrido[4,3-b]carbazole (5) was obtained. The new compound showed significant cytostatic activity for cultured L1210 cells and no inhibition of growth of the E. coli O56 strain was observed. The bactericidal activity of normal human serum against E. coli O56 was not affected by the examined compound 5 and its isomer 4.
Keywords: Olivacine; 1-substituted-6H-pyrido[4,3-b]carbazole; cytotoxicity Olivacine; 1-substituted-6H-pyrido[4,3-b]carbazole; cytotoxicity
MDPI and ACS Style

Jasztold-Howorko, R.; Doroszkiewicz, W.; Bugla-Płoskońska, G.; Croisy, A.; Carrez, D. The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative. Sci. Pharm. 2005, 73, 101-112. https://doi.org/10.3797/scipharm.aut-05-09

AMA Style

Jasztold-Howorko R, Doroszkiewicz W, Bugla-Płoskońska G, Croisy A, Carrez D. The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative. Scientia Pharmaceutica. 2005; 73(3):101-112. https://doi.org/10.3797/scipharm.aut-05-09

Chicago/Turabian Style

Jasztold-Howorko, Ryszard, Włodzimierz Doroszkiewicz, Gabriela Bugla-Płoskońska, Alain Croisy, and Daniele Carrez. 2005. "The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative" Scientia Pharmaceutica 73, no. 3: 101-112. https://doi.org/10.3797/scipharm.aut-05-09

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