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30 September 2005

The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative

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1
Wroclaw University of Medicine, Faculty of Pharmacy, Department of Organic Chemistry, ul. Grodzka 9, 50-1 37 Wroclaw, Poland
2
Institute of Genetic and Microbiology Wroclaw University, ul. Przybyszewskiego 63/72, 51-148 Wrocław, Poland
3
lnstitut Curie Recherche, Bâtiment 112, Centre Universitaire - 91405 Orsay cedex, France
*
Author to whom correspondence should be addressed.
Sci. Pharm.2005, 73(3), 101-112;https://doi.org/10.3797/scipharm.aut-05-09
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Abstract

Starting from 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine and 2-methylisonicotinic acid, 9-hydroxy-5,6-dimethyl-1-(2-methylpyridin-4-yl)-6H-pyrido[4,3-b]carbazole (5) was obtained. The new compound showed significant cytostatic activity for cultured L1210 cells and no inhibition of growth of the E. coli O56 strain was observed. The bactericidal activity of normal human serum against E. coli O56 was not affected by the examined compound 5 and its isomer 4.

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