Next Article in Journal
Polymeric Proanthocyanidins from Psidium guajava
Previous Article in Journal
Synthesis of Thienopyridines and Isoquinolines from 6-Amino-1,2-dihydro-4-methyl-2-thioxopyridine-3,5-dicarbonitrile and of Phthalazines from Thieno[3,4-c]pyridazine
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 73
Issue 3
10.3797/scipharm.aut-05-09
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative

by
Ryszard Jasztold-Howorko
1,
Włodzimierz Doroszkiewicz
2,*,
Gabriela Bugla-Płoskońska
2,
Alain Croisy
3 and
Daniele Carrez
3
1
Wroclaw University of Medicine, Faculty of Pharmacy, Department of Organic Chemistry, ul. Grodzka 9, 50-1 37 Wroclaw, Poland
2
Institute of Genetic and Microbiology Wroclaw University, ul. Przybyszewskiego 63/72, 51-148 Wrocław, Poland
3
lnstitut Curie Recherche, Bâtiment 112, Centre Universitaire - 91405 Orsay cedex, France
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2005, 73(3), 101-112; https://doi.org/10.3797/scipharm.aut-05-09
Submission received: 29 October 2004 / Accepted: 20 March 2005 / Published: 30 September 2005
Versions Notes

Abstract

Starting from 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine and 2-methylisonicotinic acid, 9-hydroxy-5,6-dimethyl-1-(2-methylpyridin-4-yl)-6H-pyrido[4,3-b]carbazole (5) was obtained. The new compound showed significant cytostatic activity for cultured L1210 cells and no inhibition of growth of the E. coli O56 strain was observed. The bactericidal activity of normal human serum against E. coli O56 was not affected by the examined compound 5 and its isomer 4.
Keywords: Olivacine; 1-substituted-6H-pyrido[4,3-b]carbazole; cytotoxicity Olivacine; 1-substituted-6H-pyrido[4,3-b]carbazole; cytotoxicity

Share and Cite

MDPI and ACS Style

Jasztold-Howorko, R.; Doroszkiewicz, W.; Bugla-Płoskońska, G.; Croisy, A.; Carrez, D. The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative. Sci. Pharm. 2005, 73, 101-112. https://doi.org/10.3797/scipharm.aut-05-09

AMA Style

Jasztold-Howorko R, Doroszkiewicz W, Bugla-Płoskońska G, Croisy A, Carrez D. The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative. Scientia Pharmaceutica. 2005; 73(3):101-112. https://doi.org/10.3797/scipharm.aut-05-09

Chicago/Turabian Style

Jasztold-Howorko, Ryszard, Włodzimierz Doroszkiewicz, Gabriela Bugla-Płoskońska, Alain Croisy, and Daniele Carrez. 2005. "The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative" Scientia Pharmaceutica 73, no. 3: 101-112. https://doi.org/10.3797/scipharm.aut-05-09

APA Style

Jasztold-Howorko, R., Doroszkiewicz, W., Bugla-Płoskońska, G., Croisy, A., & Carrez, D. (2005). The Synthesis and Bioloqical Properties of a 1-(2-Methylpyridin-4-yl) Olivacine Derivative. Scientia Pharmaceutica, 73(3), 101-112. https://doi.org/10.3797/scipharm.aut-05-09

Article Metrics

Back to TopTop