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Article

Study of Local Anesthetics. Part* 168 Critical Micelle Concentration of Alkyloxy Homoloqs of Local Anesthetic Heptacainium Chloride Determined by Ion Sensitive Electrode

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Department of Pharmaceutical Chemistry
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Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Odbojarov 10, 832 32 Bratislava, Slovak Republic
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Authors to whom correspondence should be addressed.
Sci. Pharm. 2005, 73(1), 17-25; https://doi.org/10.3797/scipharm.aut-05-02
Received: 18 October 2005 / Accepted: 10 February 2005 / Published: 30 March 2005
The critical micelle concentrations (c.m.c.) of alkyloxy homologs of local anesthetic N-[2-(2-alkyloxyphenylcarbamolyoxy)-ethyl]-piperidinium chloride (CnA) with n=3, 5, 7, 8, 10 and 12 carbons in alkyloxy substituent determined by surfactant ion sensitive electrode (ISE) depend exponentially on n: lnc.m.c.=0.70+0.49n and lnc.m.c.=0.57+0.62n at t=25 °C and pH≈4.5 in water and 0.1 mol.l-1 NaCl solution, respectively, where the free energy of transfer of the alkyloxymethylene group from the aqueous phase into the micelle hydrophobic interior is ΔG0=(-0.49±0.008)RT in water and ΔG0=(-The critical micelle concentrations (c.m.c.) of alkyloxy homologs of local anesthetic N-[2-(2-alkyloxyphenylcarbamolyoxy)-ethyl]-piperidinium chloride (CnA) with n=3, 5, 7, 8, 10 and 12 carbons in alkyloxy substituent determined by surfactant ion sensitive electrode (ISE) depend exponentially on n: lnc.m.c.=0.70+0.49n and lnc.m.c.=0.57+0.62n at t=25 °C and pH≈4.5 in water and 0.1 mol.l-1 NaCl solution, respectively, where the free energy of transfer of the alkyloxymethylene group from the aqueous phase into the micelle hydrophobic interior is ΔG0=(-0.49±0.008)RT in water and ΔG0=(-0.62±0.06)RT in the 0.1 mol.l-1 NaCl solution. The enthalpic and entropic contributions to the standard Gibbs energy of micellization of heptacainium chloride (heptyloxy homologs of CnA) in 0.1 mol.l-1 NaCl solution were calculated according to the phase separation model in the temperature range of 25-45 °C.0.62±0.06)RT in the 0.1 mol.l-1 NaCl solution. The enthalpic and entropic contributions to the standard Gibbs energy of micellization of heptacainium chloride (heptyloxy homologs of CnA) in 0.1 mol.l-1 NaCl solution were calculated according to the phase separation model in the temperature range of 25-45 °C.
Keywords: Heptacainium chloride; ion sensitive electrode; rnicellization Heptacainium chloride; ion sensitive electrode; rnicellization
MDPI and ACS Style

A ndriamainty, F.; Čižmárik, J.; Uhríková, D.; Balgavý, P. Study of Local Anesthetics. Part* 168 Critical Micelle Concentration of Alkyloxy Homoloqs of Local Anesthetic Heptacainium Chloride Determined by Ion Sensitive Electrode. Sci. Pharm. 2005, 73, 17-25. https://doi.org/10.3797/scipharm.aut-05-02

AMA Style

A ndriamainty F, Čižmárik J, Uhríková D, Balgavý P. Study of Local Anesthetics. Part* 168 Critical Micelle Concentration of Alkyloxy Homoloqs of Local Anesthetic Heptacainium Chloride Determined by Ion Sensitive Electrode. Scientia Pharmaceutica. 2005; 73(1):17-25. https://doi.org/10.3797/scipharm.aut-05-02

Chicago/Turabian Style

A ndriamainty, F., J. Čižmárik, D. Uhríková, and P. Balgavý 2005. "Study of Local Anesthetics. Part* 168 Critical Micelle Concentration of Alkyloxy Homoloqs of Local Anesthetic Heptacainium Chloride Determined by Ion Sensitive Electrode" Scientia Pharmaceutica 73, no. 1: 17-25. https://doi.org/10.3797/scipharm.aut-05-02

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