N-(3,4-Dichlorobenzyl)azoles—Investigations Regarding Synthesis, NMR-Spectroscopy and Affinity Towards Sisma-1 and Sigma-2 Receptors

Wolfgang Holzer; Bettina Brandstätter; Christine Jäger; Michael Kaun; Thierry Langer; Wayne D. Bowen

doi:10.3797/scipharm.aut-04-16

You are currently viewing a new version of our website. To view the old version click .

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Article

1 September 2004

N-(3,4-Dichlorobenzyl)azoles—Investigations Regarding Synthesis, NMR-Spectroscopy and Affinity Towards Sisma-1 and Sigma-2 Receptors

and

Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1 090 Vienna, Austria

Institute of Pharmacy, University of lnnsbruck, lnnrain 52, A-6020 Innsbruck, Austria

Unit on Receptor Biochemistry and Pharmacology, Laboratory of Medicinal Chemistry, National Institutes of Diabetes and Digestive and Kidney Diseases, National lnstitutes of Health, Bethesda, MD 20892-0815, USA

Author to whom correspondence should be addressed.

Sci. Pharm.2004, 72(3), 197-211;https://doi.org/10.3797/scipharm.aut-04-16

Version Notes

Order Reprints

Abstract

A series of azoles and aminoazoles with a 3,4-dichlorobenzyl moiety attached to a ring nitrogen atom was synthesized via reaction of the parent systems with 3,4-dichlorobenzyl chloride. Regioisomeric products were discriminated on the basis of ¹³C-NMR data or by NOE-difference spectroscopy. The affinities of some representatives towards sigma-1 and sigma-2 receptors were determined by receptor binding assays.

Keywords:

Sigma Receptors; Azoles; Alkylation; ¹³C-NMR Spectroscopy; NOE-Difference Spectroscopy

Article Metrics

Citations

Article Access Statistics

Journal Statistics

Multiple requests from the same IP address are counted as one view.

Study of Local Anesthetics. Part* 168 Critical Micelle Concentration of Alkyloxy Homoloqs of Local Anesthetic Heptacainium Chloride Determined by Ion Sensitive Electrode

A VALIDATED HPLC-ASSAY FOR THE DETERMINATION OF MELOXICAM IN PRESENCE OF ITS DEGRADATION PRODUCTS