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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Article

Application of Ion Associate Formation for Conductimetric Determination of Dothiepin Hvdrochloride in Pharmaceutical Formulations by Using Trioxalato Complexes

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Sci. Pharm. 2005, 73(1), 1-15; https://doi.org/10.3797/scipharm.aut-05-01
Received: 12 November 2004 / Accepted: 10 February 2005 / Published: 30 March 2005
A simple titrimetric method is described for the determination of dothiepin hydrochloride. The method is based on titrating the cited drug with potassium salts of trioxalato-ferrate (III) (TOXFe), trioxalato-chromate (III) (TOXCr), trioxalatoaluminate (III) (TOXAI) and trioxalato-cobaltate (III) (TOXCo). The end point was located conductimetrically. The effect of solvent, molar ratio, reagent concentration and temperature were studied. Based on conductimetric measurements at 25 °C, the solubility, solubility product, free energy (ΔG) and entropy changes (ΔS) of the ion associates were calculated. Calculations of the enthalpy change (ΔH) are based on atomic absorption measurements of the solubility of the ion associates at different temperatures. The method allowed the determination of 6.63-29.87, 3.31-49.78, 9.95-49.78 and 3.31-33.19 mg of the studied drug using TOXFe, TOXCr, TOXAl and TOXCo, respectively. The method was further applied successfully to some dosage forms containing the cited drug, and the obtained results were compared favorably with those previously given by the official method.
Keywords: Dothiepin hydrochloride (Dosulepin HCI); Conductimetry; Trioxalatocomplexes; ion associate Dothiepin hydrochloride (Dosulepin HCI); Conductimetry; Trioxalatocomplexes; ion associate
MDPI and ACS Style

Youssef, A.F.A. Application of Ion Associate Formation for Conductimetric Determination of Dothiepin Hvdrochloride in Pharmaceutical Formulations by Using Trioxalato Complexes. Sci. Pharm. 2005, 73, 1-15. https://doi.org/10.3797/scipharm.aut-05-01

AMA Style

Youssef AFA. Application of Ion Associate Formation for Conductimetric Determination of Dothiepin Hvdrochloride in Pharmaceutical Formulations by Using Trioxalato Complexes. Scientia Pharmaceutica. 2005; 73(1):1-15. https://doi.org/10.3797/scipharm.aut-05-01

Chicago/Turabian Style

Youssef, Ahmed F.A. 2005. "Application of Ion Associate Formation for Conductimetric Determination of Dothiepin Hvdrochloride in Pharmaceutical Formulations by Using Trioxalato Complexes" Scientia Pharmaceutica 73, no. 1: 1-15. https://doi.org/10.3797/scipharm.aut-05-01

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