Next Article in Journal
Construction and Evaluation of Scopolamine Ion- Selective Electrode
Previous Article in Journal
Betrachtungen zur Herstellung von Methadon-nitril und Isomethadon-nitril sowie verwandten Verbindungen
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle

The Use of Charge-Transfer Complexation in The Spectrophotometric Determination of Amlodipine Besylate

1
KSU, Faculty of Science and Arts, 46100, Kahramanmaraș, Turkey
2
A.U, Faculty of Phannazie, 06100, Ankara, Turkey
3
Ç. Ü, Faculty of Science and Arts, 01330, Adana, Turkey
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(3), 235-246; https://doi.org/10.3797/scipharm.aut-00-22
Received: 20 December 1999 / Revised: 29 May 2000 / Accepted: 29 May 2000 / Published: 17 July 2000
A simple and sensitive analytical method has been developed for the spectrophotometric assay of amlodipine besylate (ADB) in pure forms and tablets have been described. The method is based on the formation of a charge-transfer complex between the drug and tetrachloquinone (TCQ). This complex exhibit intense absorption bands in the electronic spectrum. The molecular ratio of the reactant in the complex was established and the experimental conditions leading to maximum charge-transfer band was also studied. The reaction proceeds quantitatively at pH 9 and 55°C for 10 min, the absorbance was measured at 346 nm. The method was applied to commercially available tablets and the results were statistically compared wrth those obtained by UV spectrophotometric method, using Newman-Keuls tests. In our method, Beer's Law limits to 5-25 µg/ml. The optimum experimental parameters for colour production with reagent were studied and incorporated into procedure.
Keywords: Amlodipine Besylate; Chloranil; Charge-Transfer Complex; Spectrophotometry; Pharmaceutical formulatiom Amlodipine Besylate; Chloranil; Charge-Transfer Complex; Spectrophotometry; Pharmaceutical formulatiom
MDPI and ACS Style

Gölcü, A.; Yücesoy, C.; Serin, S. The Use of Charge-Transfer Complexation in The Spectrophotometric Determination of Amlodipine Besylate. Sci. Pharm. 2000, 68, 235-246.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop