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Volume 68
Issue 3
10.3797/scipharm.aut-00-22
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Article

The Use of Charge-Transfer Complexation in The Spectrophotometric Determination of Amlodipine Besylate

by
Ayșegül (Yardımcı) Gölcü
1,
Cem Yücesoy
2 and
Selahattin Serin
1,3,*
1
KSU, Faculty of Science and Arts, 46100, Kahramanmaraș, Turkey
2
A.U, Faculty of Phannazie, 06100, Ankara, Turkey
3
Ç. Ü, Faculty of Science and Arts, 01330, Adana, Turkey
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(3), 235-246; https://doi.org/10.3797/scipharm.aut-00-22
Submission received: 20 December 1999 / Revised: 29 May 2000 / Accepted: 29 May 2000 / Published: 17 July 2000
Versions Notes

Abstract

A simple and sensitive analytical method has been developed for the spectrophotometric assay of amlodipine besylate (ADB) in pure forms and tablets have been described. The method is based on the formation of a charge-transfer complex between the drug and tetrachloquinone (TCQ). This complex exhibit intense absorption bands in the electronic spectrum. The molecular ratio of the reactant in the complex was established and the experimental conditions leading to maximum charge-transfer band was also studied. The reaction proceeds quantitatively at pH 9 and 55°C for 10 min, the absorbance was measured at 346 nm. The method was applied to commercially available tablets and the results were statistically compared wrth those obtained by UV spectrophotometric method, using Newman-Keuls tests. In our method, Beer's Law limits to 5-25 µg/ml. The optimum experimental parameters for colour production with reagent were studied and incorporated into procedure.
Keywords: Amlodipine Besylate; Chloranil; Charge-Transfer Complex; Spectrophotometry; Pharmaceutical formulatiom Amlodipine Besylate; Chloranil; Charge-Transfer Complex; Spectrophotometry; Pharmaceutical formulatiom

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MDPI and ACS Style

Gölcü, A.; Yücesoy, C.; Serin, S. The Use of Charge-Transfer Complexation in The Spectrophotometric Determination of Amlodipine Besylate. Sci. Pharm. 2000, 68, 235-246. https://doi.org/10.3797/scipharm.aut-00-22

AMA Style

Gölcü A, Yücesoy C, Serin S. The Use of Charge-Transfer Complexation in The Spectrophotometric Determination of Amlodipine Besylate. Scientia Pharmaceutica. 2000; 68(3):235-246. https://doi.org/10.3797/scipharm.aut-00-22

Chicago/Turabian Style

Gölcü, Ayșegül (Yardımcı), Cem Yücesoy, and Selahattin Serin. 2000. "The Use of Charge-Transfer Complexation in The Spectrophotometric Determination of Amlodipine Besylate" Scientia Pharmaceutica 68, no. 3: 235-246. https://doi.org/10.3797/scipharm.aut-00-22

APA Style

Gölcü, A., Yücesoy, C., & Serin, S. (2000). The Use of Charge-Transfer Complexation in The Spectrophotometric Determination of Amlodipine Besylate. Scientia Pharmaceutica, 68(3), 235-246. https://doi.org/10.3797/scipharm.aut-00-22

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